ArticleClinical journal of the American Society of Nephrology : CJASN2014
Presence and outcomes of kidney disease in patients with pulmonary hypertension.
Article in Clinical journal of the American Society of Nephrology : CJASN, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 34 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Predictive Value of Renal Venous Flow Profiles for Adverse Outcomes in Right Heart Failure
Prospective Evaluation of Changes in Renal Function and Body Composition in Patients With Pulmonary Hypertension
Prevalence and Predictors of Kidney Disease, and Long-Term Renal Outcome in Pulmonary Hypertension
Who cites it
34 citing papers in PubMed, 63 citations in OpenAlex.
- Renal Recovery Patterns and Long-Term Kidney Function Decline in Pulmonary Hypertension.Pulmonary circulation · 2026Article
- Prevalence and risk factors of pulmonary hypertension in maintenance hemodialysis patients based on echocardiography.Medicine · 2026Article
- Haemodynamically irrelevant pericardial effusion is associated with increased mortality in maintenance hemodialysis patients with end-stage renal disease.BMC nephrology · 2025Article
- Renal Outcomes After Lung or Combined Heart-Lung Transplantation in Pulmonary Hypertension.Pulmonary circulation · 2025Article
- Tricuspid Annular Plane Systolic Excursion/Systolic Pulmonary Artery Pressure Ratio and Cardiorenal Syndrome Type 2 in the Systemic Sclerosis EUSTAR Cohort.Arthritis care & research · 2025Article
- Pulmonary hypertension and chronic kidney disease: prevalence, pathophysiology and outcomes.Nature reviews. Nephrology · 2024Review
- Phenotype and outcomes according to loop diuretic use in pulmonary arterial hypertension.ESC heart failure · 2024Observational
- Kidney Dysfunction, Hepatic Impairment, and Lipid Metabolism Abnormalities in Patients with Precapillary Pulmonary Hypertension.Diagnostics (Basel, Switzerland) · 2024Article
- Hemodynamic response to inhaled nitric oxide in patients with pulmonary hypertension and chronic kidney disease: A retrospective cohort study.Pulmonary circulation · 2024Article
- Prognostic implication of glomerular filtration rates in patients with chronic thromboembolic pulmonary hypertension who have undergone balloon pulmonary angioplasty.Experimental and therapeutic medicine · 2024Article
- Associations between eGFR and albuminuria with right ventricular measures: the MESA-Right Ventricle study.Clinical kidney journal · 2023Article
- The potential of cystatin C as a predictive biomarker in pulmonary hypertension.BMC pulmonary medicine · 2023Article
- Pulmonary hypertension without heart failure causes cardiorenal syndrome in a porcine model.Scientific reports · 2023Article
- Association Between Left Ventricular Geometry and Renal Outcomes in Patients With Chronic Kidney Disease: Findings From Korean Cohort Study for Outcomes in Patients With Chronic Kidney Disease Study.Frontiers in cardiovascular medicine · 2022Article
- Gender dimension in cardio-pulmonary continuum.Frontiers in cardiovascular medicine · 2022Review
- Mortality, Kidney Failure, and Hospitalization Among Medicare Beneficiaries With CKD and Pulmonary Hypertension.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2021Observational
- [Renal insufficiency in the context of cardio-pulmonary-renal pathophysiology].Der Internist · 2021Review
- Kidney Transplantation Confers Survival Benefit for Candidates With Pulmonary Hypertension.Transplantation direct · 2021Article
- Congestive nephropathy: a neglected entity? Proposal for diagnostic criteria and future perspectives.ESC heart failure · 2021Review
- Echocardiography to Screen for Pulmonary Hypertension in CKD.Kidney international reports · 2020Article
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 2 countries.
Funding
Abstract
BACKGROUND AND
objectivesPulmonary hypertension is associated with higher mortality rates. The associations of nondialysis-dependent CKD and all-cause mortality in patients with pulmonary hypertension were studied. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: The study population included those patients who underwent right heart catheterization for confirmation of pulmonary hypertension between 1996 and January 2011. Pulmonary hypertension was defined as the presence of mean pulmonary artery pressure ≥ 25 mmHg at rest measured by right heart catheterization. CKD was defined as the presence of two measurements of eGFR<60 ml/min per 1.73 m(2) 90 days apart. The risk factors associated with CKD as well as the association between CKD and death in those patients with pulmonary hypertension using logistic regression and Cox proportional hazard models were examined.
resultsOf 1088 patients with pulmonary hypertension, 388 (36%) patients had CKD: 340 patients had stage 3 CKD, and 48 (4%) patients had stage 4 CKD. In the multivariable analysis, older age, higher hemoglobin, and higher mean right atrial pressures were independently associated with CKD. During a median follow-up of 3.2 years (interquartile range=1.5-5.6 years), 559 patients died. After adjusting for relevant covariates, presence of stage 3 CKD (hazard ratio, 1.37; 95% confidence interval, 1.14 to 1.66) and stage 4 CKD (hazard ratio, 2.69; 95% confidence interval, 1.88 to 3.86) was associated with all-cause mortality in those patients with pulmonary hypertension. When eGFR was examined as a continuous measure, a 5 ml/min per 1.73 m(2) lower eGFR was associated with a 5% (95% confidence interval, 1.03 to 1.07) higher hazard for death. This higher risk with CKD was similar irrespective of demographics, left ventricular function, and pulmonary capillary wedge pressure.
conclusionIn a clinical population referred for right heart catheterization, presence of CKD was associated with higher all-cause mortality in those patients with pulmonary hypertension. Mechanisms that may underlie these associations warrant additional studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.