ArticleHuman brain mapping2014
Placebo analgesia and reward processing: integrating genetics, personality, and intrinsic brain activity.
Article in Human brain mapping, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
49 citing papers in PubMed, 77 citations in OpenAlex.
- Is it personality or genes? - A secondary analysis on a randomized controlled trial investigating responsiveness to placebo analgesia.Scandinavian journal of pain · 2025Trial
- Manipulating placebo analgesia and nocebo hyperalgesia by changing brain excitability.Proceedings of the National Academy of Sciences of the United States of America · 2021Trial
- Open-label placebo reduces fatigue in cancer survivors: a randomized trial.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2019Trial
- Enhancing treatment of osteoarthritis knee pain by boosting expectancy: A functional neuroimaging study.NeuroImage. Clinical · 2018Trial
- Brain Connectivity Predicts Placebo Response across Chronic Pain Clinical Trials.PLoS biology · 2016Trial
- Genetic variation in catechol-O-methyltransferase modifies effects of clonidine treatment in chronic fatigue syndrome.The pharmacogenomics journal · 2016Trial
- Acupuncture modulates cortical thickness and functional connectivity in knee osteoarthritis patients.Scientific reports · 2014Trial
- Open-label placebo effects on psychological distress and hair cortisol in a randomized controlled trial - the moderating role of the five-factor personality traits.Comprehensive psychoneuroendocrinology · 2026Article
- The Role of Oxytocin and Sex in Analgesic Placebo-Response: Exploratory Analysis from a Sham Randomized Clinical Trial in Chronic Back-Pain Patients.Journal of clinical medicine · 2025Article
- Transcriptomic Profiles Associated with Experimental Placebo Effects in Chronic Pain.Clinical pharmacology and therapeutics · 2024Article
- The Placebo Effect in Psychosis: Why It Matters and How to Measure It.Biological psychiatry global open science · 2023Review
- When knowledge hurts: humans are willing to receive pain for obtaining non-instrumental information.Proceedings. Biological sciences · 2023Article
- Placebo and nocebo effects: from observation to harnessing and clinical application.Translational psychiatry · 2022Review
- Thalamic altered spontaneous activity and connectivity in obstructive sleep apnea syndrome.Journal of neuroimaging : official journal of the American Society of Neuroimaging · 2022Article
- Functional connectivity impairment of thalamus-cerebellum-scratching neural circuits in pruritus of chronic spontaneous urticaria.Frontiers in neuroscience · 2022Article
- Do individual psychological characteristics predict induction and generalization of nocebo and placebo effects on pain and itch?Frontiers in psychiatry · 2022Article
- Genotypes of Pain and Analgesia in a Randomized Trial of Irritable Bowel Syndrome.Frontiers in psychiatry · 2022Article
- Associations Between Interindividual Differences, Expectations and Placebo and Nocebo Effects in Itch.Frontiers in psychology · 2021Article
- Cell-Type-Specific Gene Modules Related to the Regional Homogeneity of Spontaneous Brain Activity and Their Associations With Common Brain Disorders.Frontiers in neuroscience · 2021Article
- Pain modulates neural responses to reward in the medial prefrontal cortex.Human brain mapping · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Our expectations about an event can strongly shape our subjective evaluation and actual experience of events. This ability, applied to the modulation of pain, has the potential to affect therapeutic analgesia substantially and constitutes a foundation for non-pharmacological pain relief. A typical example of such modulation is the placebo effect. Studies indicate that placebo may be regarded as a reward, and brain activity in the reward system is involved in this modulation process. In the present study, we combined resting-state functional magnetic resonance imaging (rs-fMRI) measures, genotype at a functional COMT polymorphism (Val158Met), and personality measures in a model to predict the magnitude of placebo conditioning effect indicated by subjective pain rating reduction to calibrated noxious stimuli. We found that the regional homogeneity (ReHo), an index of local neural coherence, in the ventral striatum, was significantly associated with conditioning effects on pain rating changes. We also found that the number of Met alleles at the COMT polymorphism was linearly correlated to the suppression of pain. In a fitted regression model, we found the ReHo in the ventral striatum, COMT genotype, and Openness scores accounted for 59% of the variance in the change in pain ratings. The model was further tested using a separate data set from the same study. Our findings demonstrate the potential of combining resting-state connectivity, genetic information, and personality to predict placebo effect.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.