ArticleHuman brain mapping2014
Altered structural brain connectome in young adult fragile X premutation carriers.
Article in Human brain mapping, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 15 citations in OpenAlex.
- Open-Label Allopregnanolone Treatment of Men with Fragile X-Associated Tremor/Ataxia Syndrome.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2017Trial
- CNS critical periods: implications for dystonia and other neurodevelopmental disorders.JCI insight · 2021Review
- A GENERALIZED FRAMEWORK OF PATHLENGTH ASSOCIATED COMMUNITY ESTIMATION FOR BRAIN STRUCTURAL NETWORK.Proceedings. IEEE International Symposium on Biomedical Imaging · 2020Article
- Inhibition deficits are modulated by age and CGG repeat length in carriers of the FMR1 premutation allele who are mothers of children with fragile X syndrome.Brain and cognition · 2020Article
- Global and Local Connectivity Differences Converge With Gene Expression in a Neurodevelopmental Disorder of Known Genetic Origin.Cerebral cortex (New York, N.Y. : 1991) · 2017Article
- Abnormal trajectories in cerebellum and brainstem volumes in carriers of the fragile X premutation.Neurobiology of aging · 2017Article
- Altered Brain Network Segregation in Fragile X Syndrome Revealed by Structural Connectomics.Cerebral cortex (New York, N.Y. : 1991) · 2017Article
- Disassociation between brain activation and executive function in fragile X premutation females.Human brain mapping · 2017Article
- Executive Dysfunction in Female FMR1 Premutation Carriers.Cerebellum (London, England) · 2016Article
- The fragile X mental retardation 1 gene (FMR1): historical perspective, phenotypes, mechanism, pathology, and epidemiology.The Clinical neuropsychologist · 2016Review
- Estimating individual contribution from group-based structural correlation networks.NeuroImage · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
Fragile X premutation carriers (fXPC) are characterized by 55-200 CGG trinucleotide repeats in the 5' untranslated region on the Xq27.3 site of the X chromosome. Clinically, they are associated with the fragile X-Associated Tremor/Ataxia Syndrome, a late-onset neurodegenerative disorder with diffuse white matter neuropathology. Here, we conducted first-ever graph theoretical network analyses in fXPCs using 30-direction diffusion-weighted magnetic resonance images acquired from 42 healthy controls aged 18-44 years (HC; 22 male and 20 female) and 46 fXPCs (16 male and 30 female). Globally, we found no differences between the fXPCs and HCs within each gender for all global graph theoretical measures. In male fXPCs, global efficiency was significantly negatively associated with the number of CGG repeats. For nodal measures, significant group differences were found between male fXPCs and male HCs in the right fusiform and the right ventral diencephalon (for nodal efficiency), and in the left hippocampus [for nodal clustering coefficient (CC)]. In female fXPCs, CC in the left superior parietal cortex correlated with counting performance in an enumeration task.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.