ArticleHuman brain mapping2014
Subclinical cognitive decline in middle-age is associated with reduced task-induced deactivation of the brain's default mode network.
Article in Human brain mapping, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 51 citations in OpenAlex.
- Effects of G.H.3. On mental symptoms and health-related quality of life among older adults: results of a three-month follow-Up study in Shanghai, China.Nutrition journal · 2016Trial
- Elevated p16ink4a Expression in Human Labial Salivary Glands as a Potential Correlate of Cognitive Aging in Late Midlife.PloS one · 2016Trial
- Functional neuroplasticity of facilitation and interference effects on inhibitory control following 3-month physical exercise in aging.Scientific reports · 2024Article
- Changes in Brain Activation Patterns During Working Memory Tasks in People With Post-COVID Condition and Persistent Neuropsychiatric Symptoms.Neurology · 2023Article
- Sex differences in default mode network connectivity in healthy aging adults.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Functional brain rewiring and altered cortical stability in ulcerative colitis.Molecular psychiatry · 2022Article
- Regularity and randomness in ageing: Differences in resting-state EEG complexity measured by largest Lyapunov exponent.Neuroimage. Reports · 2021Article
- Functional MRI Shows Altered Deactivation and a Corresponding Decrease in Functional Connectivity of the Default Mode Network in Patients with Gliomas.AJNR. American journal of neuroradiology · 2021Article
- Default mode network integrity changes contribute to cognitive deficits in subcortical vascular cognitive impairment, no dementia.Brain imaging and behavior · 2021Article
- Object-Location Memory Training in Older Adults Leads to Greater Deactivation of the Dorsal Default Mode Network.Frontiers in human neuroscience · 2021Article
- Discovering correlates of age-related decline in a healthy late-midlife male birth cohort.Aging · 2020Article
- Discovering markers of healthy aging: a prospective study in a Danish male birth cohort.Aging · 2019Article
- Sleep efficiency and neurophysiological patterns in middle-aged men are associated with cognitive change over their adult life course.Journal of sleep research · 2019Article
- Brain Responses to Passive Sensory Stimulation Correlate With Intelligence.Frontiers in aging neuroscience · 2019Article
- Evidence of parietal hyperactivation in individuals with mild cognitive impairment who progressed to dementia: A longitudinal fMRI study.NeuroImage. Clinical · 2019Article
- Neurocompensatory Effects of the Default Network in Older Adults.Frontiers in aging neuroscience · 2019Article
- Subclinical depressive symptoms during late midlife and structural brain alterations: A longitudinal study of Danish men born in 1953.Human brain mapping · 2018Article
- Hyposalivation and Poor Dental Health Status Are Potential Correlates of Age-Related Cognitive Decline in Late Midlife in Danish Men.Frontiers in aging neuroscience · 2018Article
- Intranetwork and internetwork connectivity in patients with Alzheimer disease and the association with cerebrospinal fluid biomarker levels.Journal of psychiatry & neuroscience : JPN · 2017Article
- Targeting Neural Hyperactivity as a Treatment to Stem Progression of Late-Onset Alzheimer's Disease.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2017Review
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cognitive abilities decline with age, but with considerable individual variation. The neurobiological correlate of this variation is not well described. Functional brain imaging studies have demonstrated reduced task-induced deactivation (TID) of the brain's default mode network (DMN) in a wide range of neurodegenerative diseases involving cognitive symptoms, in conditions with increased risk of Alzheimer's disease, and even in advanced but healthy aging. Here, we investigated brain activation and deactivation during a visual-motor task in 185 clinically healthy males from a Danish birth cohort, whose cognitive function was assessed in youth and midlife. Using each individual as his own control, we defined a group with a large degree of cognitive decline, and a control group. When correcting for effects of total cerebral blood flow and hemoglobin level, we found reduced TID in the posterior region of the DMN in the cognitive decline group compared to the control group. Furthermore, increased visual activation response was found in the cognitive decline group, indicating that the TID reduction was not exclusively due to overall impaired vascular reactivity. These results suggest a neurobiological basis for subclinical cognitive decline in late midlife, which includes TID alterations similar to the pattern seen in patients with AD and mild cognitive impairment. Hence, TID reduction might be suggested as an early marker for subtle cognitive decline in aging.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.