ArticleEuropean journal of nuclear medicine and molecular imaging2014
Sites of latest mechanical activation as assessed by SPECT myocardial perfusion imaging in ischemic and dilated cardiomyopathy patients with LBBB.
Article in European journal of nuclear medicine and molecular imaging, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Prognostic value of mechanical dyssynchrony in patients with heart failure: a systematic review.BMC cardiovascular disorders · 2024Pooled it
- Predictive values of left ventricular mechanical dyssynchrony for CRT response in heart failure patients with different pathophysiology.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022Article
- Relationship between left ventricular mechanical synchrony and left ventricular systolic function: a CZT-SPECT analysis.BMC cardiovascular disorders · 2022Article
- Prognostic value of integrative analysis of electrical and mechanical dyssynchrony in patients with acute heart failure.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Article
- Useful assessment of myocardial viability and dyssynchrony from gated perfusion scintigraphy for better qualification for resynchronization therapy. Part 3.Kardiochirurgia i torakochirurgia polska = Polish journal of cardio-thoracic surgery · 2020Review
- Myocardial viability as integral part of the diagnostic and therapeutic approach to ischemic heart failure.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2015Review
- Cardiac Resynchronization Therapy in Non-Ischemic Cardiomyopathy.Journal of atrial fibrillationReview
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4 authors.
Funding
Abstract
objectiveSites of latest mechanical activation (SOLA) have been recognized as optimal left-ventricular (LV) lead positions for cardiac resynchronization therapy (CRT). This study was aimed to investigate SOLA in ischemic cardiomyopathy (ICM) and dilated cardiomyopathy (DCM) patients with left bundle branch block (LBBB).
methodsSixty-four consecutive LBBB patients (47 DCM, 17 ICM), who met the standard indications for CRT and underwent resting SPECT myocardial perfusion imaging (MPI), were selected. Phase analysis was used to assess LV dyssynchrony and SOLA. The Emory Cardiac Toolbox was used to measure perfusion defects. LV dyssynchrony and SOLA were compared between the DCM patients with wide (≥150 ms) and moderate (120-150 ms) QRS durations (QRSd). The relationship between SOLA and perfusion defects was analyzed in the ICM patients.
resultsThe DCM patients with wide QRSd had significantly more LV dyssynchrony than those with moderate QRSd. Lateral SOLA were significantly more frequent in the DCM patients with wide QRSd than those with moderate QRSd (96% vs. 62%, p = 0.010). In the ICM patients, SOLA were either in the scar segments (82%) or in the segments immediately adjacent to the scar segments (18%), regardless of QRSd.
conclusionLateral SOLA were more frequent in the DCM patients with wide QRSd than those with moderate QRSd. Such relationship was not observed in the ICM patients, where SOLA were associated with scar location rather than QRSd. These findings support the use of SPECT MPI to aid the selection of potential CRT responders and guide LV lead placement.
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