Evidence map›Paper›PMID 24577934›Full record

ArticleDepression and anxiety2014

Risk factors for anxiety disorders: common and specific effects in a national sample.

Carlos Blanco, José Rubio, Melanie Wall, Shuai Wang, Chelsea J Jiu, Kenneth S Kendler

Open access · greenAbstract read
In one paragraph

Article in Depression and anxiety, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed, 1 pooled it
8.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 1 synthesis or guideline pooled it, 149 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Carlos BlancoDepartment of Psychiatry, Columbia University, New York State Psychiatric Institute, New York, New York.
José Rubio
Melanie Wall
Shuai Wang
Chelsea J Jiu
Kenneth S Kendler
New York State Psychiatric InstituteColumbia University · USNew York Psychoanalytic Society and Institute · USVirginia Commonwealth University · US

Funding

Improving the Effectiveness of Treatment for Depression in HispanicsR01MH076051 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI BLANCO, CARLOS · 2008 to 2012
$2.8M
Towards a Comprehensive Developmental Model of Substance Use DisordersR01DA019606 · NIDA · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI OLFSON, MARK · 2006 to 2016
$2.6M
2/2 Gambling Addiction: Treatment Mediators and ModeratorsR01MH082773 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI BLANCO, CARLOS · 2009 to 2012
$1.6M
Bridging Efficacy and Effectiveness in Drug Abuse TreatmentK02DA023200 · NIDA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BLANCO, CARLOS · 2008 to 2012
$618k
NIDA NIH HHS DA019606NIDA NIH HHS DA023200NIDA NIH HHS K02 DA023200NIDA NIH HHS R01 DA019606NIMH NIH HHS MH076051NIMH NIH HHS MH082773NIMH NIH HHS R01 MH076051NIMH NIH HHS R01 MH082773
6 · The paper itself

Abstract

backgroundAnxiety disorders and major depressive disorder (MDD) often co-occur and share a broad range of risk factors. The goal of this study was to examine whether the co-occurrence of anxiety disorders and MDD could be explained by an underlying latent factor and whether the risk factors exert their effect exclusively through this factor, directly on each disorder, or through a combination of effects at both levels.

methodsData were drawn from a large, nationally representative sample. Confirmatory factor analysis was used to identify the latent structure of anxiety disorders. A multiple indicators multiple causes (MIMIC) approach was used to assess the common and specific effects of risk factors for anxiety disorders.

resultsA one-factor model provided a good fit to the co-occurrence of anxiety disorders. Low self-esteem, family history of depression, female sex, childhood sexual abuse, White race, years of education, number of traumatic experiences, and disturbed family environment increased the risk of anxiety disorders and MDD through their effect on the latent factor. There were also several direct effects of the covariates on the disorders, indicating that the effect of the covariates differed across disorders.

conclusionsRisk for anxiety disorders and MDD appears to be mediated partially by a latent variable underlying anxiety disorders and MDD, and partially by disorder-specific effects. These findings may contribute to account for the high rates of comorbidity among disorders, identify commonalities in the etiologies of these disorders, and provide clues for the development of unified preventive interventions.

Indexed as

AdolescentAdultAnxiety DisordersComorbidityFemaleHumansMajor Depressive DisorderMaleMiddle AgedRisk FactorsUnited StatesYoung Adultanxiety disorderscommon effectsconceptual modelrisk factorsspecific effects

Identifiers

PMID24577934
PMCPMC4147018
OpenAlexW1911056500

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.