ArticleTumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine2014
Association between CLPTM1L-TERT rs401681 polymorphism and pancreatic cancer risk among Chinese Han population.
Article in Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.
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Who cites it
10 citing papers in PubMed, 2 syntheses or guidelines pooled it, 12 citations in OpenAlex.
- Pooled it
- Association between CLPTM1L-TERT rs401681 polymorphism and risk of pancreatic cancer: a meta-analysis.Clinical and experimental medicine · 2015Pooled it
- The updated relationship between the cleft‑lip and palate transmembrane protein‑1‑like rs401681 and lung cancer risk: A systematic review and meta‑analysis.Molecular and clinical oncology · 2024Article
- Susceptibility loci for pancreatic cancer in the Brazilian population.BMC medical genomics · 2021Article
- Validation of genome-wide association study-identified single nucleotide polymorphisms in a case-control study of pancreatic cancer from Taiwan.Journal of biomedical science · 2020Article
- Article
- Association of gastrointestinal gland cancer susceptibility loci with esophageal carcinoma among the Chinese Han population: a case-control study.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Article
- Prognostic significance of CLPTM1L expression and its effects on migration and invasion of human lung cancer cells.Cancer biomarkers : section A of Disease markers · 2016Article
- Association of CRR9 locus with elevated risk of squamous cell carcinoma and basal cell carcinoma.International journal of clinical and experimental medicine · 2015Article
- CLPTM1L Is a Novel Putative Oncogene Promoting Tumorigenesis in Oral Squamous Cell Carcinoma.Cell transplantationArticle
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pancreatic cancer is one of the human cancers with the highest fatality rates; however, the etiology still remains largely unknown. Recently, one genome-wide association study (GWAS), conducted exclusively among women of European ancestry, has discovered that cleft lip and palate transmembrane 1-like telomerase reverse transcriptase (CLPTM1L-TERT) rs401681 polymorphism was significantly associated with pancreatic cancer risk. Few studies have been conducted to evaluate whether this finding could be generalized to Chinese people. In the current study, we explored the association between rs401681 polymorphism and risk of pancreatic cancer in a case-control study of 1,587 Chinese people (including 766 pancreatic cancer cases and 821 healthy controls). Under the log-additive model, each additional copy of minor allele T was associated with a 1.24-fold increased risk of pancreatic cancer (odds ratio (OR)=1.24, 95 % confidence interval (CI) 1.06-1.44, P=5.61 × 10(-3)). While compared with individuals with the CC genotype, the OR for developing pancreatic cancer was 1.09 (95 % CI 0.88-1.34) among those with the CT genotype and 1.66 (95 % CI 1.20-2.29) among those with the TT genotype. Additional adjustments for the confounding factors did not change the results materially. Our data suggests that the T allele of rs401681 in CLPTM1L-TERT locus predisposes its carriers to pancreatic cancer, and further research into the function of CLPTM1L-TERT locus and its potential biological mechanism association may be warranted.
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