ArticleMolecular biology reports2014
Chitin synthase A: a novel epidermal development regulation gene in the larvae of Bombyx mori.
Article in Molecular biology reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 47 citations in OpenAlex.
- Article
- Characterization of Chitin Synthase A cDNA fromInsects · 2022Article
- Molecular Characterization of UDP-Genes · 2022Article
- Glucosamine-6-phosphate N-acetyltransferase gene silencing by parental RNA interference in rice leaf folder, Cnaphalocrocis medinalis (Lepidoptera: Pyralidae).Scientific reports · 2022Article
- RNA Interference-Based Silencing of theInsects · 2020Article
- Article
- Identification, Characterization, and Functional Analysis of Chitin Synthase Genes inInternational journal of molecular sciences · 2020Article
- Role ofInternational journal of molecular sciences · 2020Article
- Glucose Utilization in the Regulation of Chitin Synthesis in Brown Planthopper.Journal of insect science (Online) · 2019Article
- Silencing of the Chitin Synthase Gene Is Lethal to the Asian Citrus Psyllid,International journal of molecular sciences · 2019Article
- Effects of RNAi-based silencing of chitin synthase gene on moulting and fecundity in pea aphids (Acyrthosiphon pisum).Scientific reports · 2019Article
- Molecular cloning, expression, and functional analysis of the chitin synthase 1 gene and its two alternative splicing variants in the white-backed planthopper, Sogatella furcifera (Hemiptera: Delphacidae).Scientific reports · 2019Article
- Comparative Analysis of the Integument Transcriptomes betweenInternational journal of molecular sciences · 2018Article
- miR-71 and miR-263 Jointly Regulate Target Genes Chitin synthase and Chitinase to Control Locust Molting.PLoS genetics · 2016Article
- RNA interference ofInternational journal of biological sciences · 2016Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chitin synthase is the key regulatory enzyme for chitin synthesis and excretion in insects, as well as a specific target of insecticides. The chitin synthase A gene (BmChsA) cloned from Bombyx mori, the model species of lepidopteran, is an epidermis-specific expressed gene during the molting stage. Knockdown BmChsA gene in 3rd instar larvae increased the number of non-molting and abnormal molting larvae. Exposure to nikkomycin Z, a chitin synthase inhibitor downregulated the expression of BmChsA and decreased the amount of epidermis chitin during the molting process. The thickness of the new epidermis and its dense structure varied greatly. The exogenous hormones significantly upregulated the expression of BmChsA with low levels of endogenous MH and high levels of endogenous JH immediately after molting. With low levels of endogenous hormones during the mulberry intake process, BmChsA was rarely upregulated by exogenous hormones. With high levels of endogenous MH and low levels of endogenous JH during the molting stage, we did not detect the upregulation of BmChsA by exogenous hormones. The expression of BmChsA was regulated by endocrine hormones, which directly affected the chitin synthesis-dependent epidermal regeneration and molting process.
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