ArticleNeurotoxicity research2014
Cadmium-induced ototoxicity in rat cochlear organotypic cultures.
Article in Neurotoxicity research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed, 30 citations in OpenAlex.
- Plasma Ionomic Profile and Interaction Patterns in Coronary Artery Disease Patients.Biological trace element research · 2025Article
- Which Environmental Pollutants Are Toxic to Our Ears?-Evidence of the Ototoxicity of Common Substances.Toxics · 2024Review
- Mechanotransduction Activity Facilitates Hair Cell Toxicity Caused by the Heavy Metal Cadmium.Frontiers in cellular neuroscience · 2020Article
- Association between cadmium exposure and hearing impairment: a population-based study in Korean adults.Yeungnam University journal of medicine · 2019Article
- Paraquat initially damages cochlear support cells leading to anoikis-like hair cell death.Hearing research · 2018Article
- Comparison of Pure-Tone Average Methods for Estimation of Hearing Loss Caused by Environmental Exposure to Lead and Cadmium: Does the Pure-Tone Average Method Which Uses Low-Frequency Ranges Underestimate the Actual Hearing Loss Caused by Environmental Lead and Cadmium Exposure?Audiology & neuro-otology · 2018Article
- Trimethyltin-induced cochlear degeneration in rat.Journal of otology · 2016Article
- Ototoxicity of Divalent Metals.Neurotoxicity research · 2016Review
- Translational Biomarkers of Neurotoxicity: A Health and Environmental Sciences Institute Perspective on the Way Forward.Toxicological sciences : an official journal of the Society of Toxicology · 2015Review
- Cobalt-Induced Ototoxicity in Rat Postnatal Cochlear Organotypic Cultures.Neurotoxicity research · 2015Article
- Characteristic anatomical structures of rat temporal bone.Journal of otology · 2015Article
- Endogenous concentrations of biologically relevant metals in rat brain and cochlea determined by inductively coupled plasma mass spectrometry.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2015Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
Cadmium (Cd), a widely used industrial metal, is extremely nephrotoxic and neurotoxic; however, its effects on the peripheral auditory system are poorly understood. To evaluate the ototoxicity of Cd, we treated cochlear organotypic cultures from postnatal day 3 rats with Cd concentrations from 10 to 500 μM for 24 or 48 h. Afterward, we evaluated the degree of damage to hair cells, auditory nerve fibers, and spiral ganglion neurons. Damage to the hair cells, auditory nerve fibers, and spiral ganglion neurons systematically increased in a dose and time-dependent manner. Exposure to Cd concentrations of 10 μM for 24 and 48 h resulted in minor inner and outer hair cell loss in the basal third of the cochlea. As Cd concentrations increased, toxicity spread toward the apex, also in a time-dependent manner. Treatment with 100 μM Cd for 48 h resulted in substantial (>30 %) hair cell loss over the entire cochlea. Cd was also toxic to auditory nerve fibers and spiral ganglion neurons; 100 μM of Cd for 24 h or 10 μM of Cd for 48 h resulted in considerable damage to auditory nerve fibers and spiral ganglion neurons. These findings are the first to demonstrate that Cd can cause significant lesions to peripheral auditory nerve fibers, spiral ganglion neurons, and sensory hair cells in organotypic cultures from postnatal cochleae.
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Registered trials
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