Evidence map›Paper›PMID 24577355›Full record

ArticleCirculation. Cardiovascular imaging2014

Noncalcified coronary plaque volumes in healthy people with a family history of early onset coronary artery disease.

Brian G Kral, Lewis C Becker, Dhananjay Vaidya, Lisa R Yanek, Rehan Qayyum, Stefan L Zimmerman, Damini Dey, Daniel S Berman, Taryn F Moy, Elliot K Fishman and 1 more

Abstract read
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In one paragraph

Article in Circulation. Cardiovascular imaging, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
3.0field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 61 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Brian G KralFrom the Johns Hopkins GeneSTAR Research Program, Department of Medicine (B.G.K., L.C.B., D.V., L.R.Y., R.Q., T.F.M., D.M.B.) and Department of Radiology (S.L.Z., E.K.F.), The Johns Hopkins Medical Institutions, Baltimore, MD; and the Biomedical Imaging Research Institute, Department of Biomedical Sciences (D.D.) and Departments of Imaging and Medicine (D.S.B.), Cedars-Sinai Medical Center, Los Angeles, CA. bkral@jhmi.edu.
Lewis C BeckerFrom the Johns Hopkins GeneSTAR Research Program, Department of Medicine (B.G.K., L.C.B., D.V., L.R.Y., R.Q., T.F.M., D.M.B.) and Department of Radiology (S.L.Z., E.K.F.), The Johns Hopkins Medical Institutions, Baltimore, MD; and the Biomedical Imaging Research Institute, Department of Biomedical Sciences (D.D.) and Departments of Imaging and Medicine (D.S.B.), Cedars-Sinai Medical Center, Los Angeles, CA.
Dhananjay VaidyaFrom the Johns Hopkins GeneSTAR Research Program, Department of Medicine (B.G.K., L.C.B., D.V., L.R.Y., R.Q., T.F.M., D.M.B.) and Department of Radiology (S.L.Z., E.K.F.), The Johns Hopkins Medical Institutions, Baltimore, MD; and the Biomedical Imaging Research Institute, Department of Biomedical Sciences (D.D.) and Departments of Imaging and Medicine (D.S.B.), Cedars-Sinai Medical Center, Los Angeles, CA.
Lisa R YanekFrom the Johns Hopkins GeneSTAR Research Program, Department of Medicine (B.G.K., L.C.B., D.V., L.R.Y., R.Q., T.F.M., D.M.B.) and Department of Radiology (S.L.Z., E.K.F.), The Johns Hopkins Medical Institutions, Baltimore, MD; and the Biomedical Imaging Research Institute, Department of Biomedical Sciences (D.D.) and Departments of Imaging and Medicine (D.S.B.), Cedars-Sinai Medical Center, Los Angeles, CA.
Rehan QayyumFrom the Johns Hopkins GeneSTAR Research Program, Department of Medicine (B.G.K., L.C.B., D.V., L.R.Y., R.Q., T.F.M., D.M.B.) and Department of Radiology (S.L.Z., E.K.F.), The Johns Hopkins Medical Institutions, Baltimore, MD; and the Biomedical Imaging Research Institute, Department of Biomedical Sciences (D.D.) and Departments of Imaging and Medicine (D.S.B.), Cedars-Sinai Medical Center, Los Angeles, CA.
Stefan L ZimmermanFrom the Johns Hopkins GeneSTAR Research Program, Department of Medicine (B.G.K., L.C.B., D.V., L.R.Y., R.Q., T.F.M., D.M.B.) and Department of Radiology (S.L.Z., E.K.F.), The Johns Hopkins Medical Institutions, Baltimore, MD; and the Biomedical Imaging Research Institute, Department of Biomedical Sciences (D.D.) and Departments of Imaging and Medicine (D.S.B.), Cedars-Sinai Medical Center, Los Angeles, CA.
Damini DeyFrom the Johns Hopkins GeneSTAR Research Program, Department of Medicine (B.G.K., L.C.B., D.V., L.R.Y., R.Q., T.F.M., D.M.B.) and Department of Radiology (S.L.Z., E.K.F.), The Johns Hopkins Medical Institutions, Baltimore, MD; and the Biomedical Imaging Research Institute, Department of Biomedical Sciences (D.D.) and Departments of Imaging and Medicine (D.S.B.), Cedars-Sinai Medical Center, Los Angeles, CA.
Daniel S BermanFrom the Johns Hopkins GeneSTAR Research Program, Department of Medicine (B.G.K., L.C.B., D.V., L.R.Y., R.Q., T.F.M., D.M.B.) and Department of Radiology (S.L.Z., E.K.F.), The Johns Hopkins Medical Institutions, Baltimore, MD; and the Biomedical Imaging Research Institute, Department of Biomedical Sciences (D.D.) and Departments of Imaging and Medicine (D.S.B.), Cedars-Sinai Medical Center, Los Angeles, CA.
Taryn F MoyFrom the Johns Hopkins GeneSTAR Research Program, Department of Medicine (B.G.K., L.C.B., D.V., L.R.Y., R.Q., T.F.M., D.M.B.) and Department of Radiology (S.L.Z., E.K.F.), The Johns Hopkins Medical Institutions, Baltimore, MD; and the Biomedical Imaging Research Institute, Department of Biomedical Sciences (D.D.) and Departments of Imaging and Medicine (D.S.B.), Cedars-Sinai Medical Center, Los Angeles, CA.
Elliot K FishmanFrom the Johns Hopkins GeneSTAR Research Program, Department of Medicine (B.G.K., L.C.B., D.V., L.R.Y., R.Q., T.F.M., D.M.B.) and Department of Radiology (S.L.Z., E.K.F.), The Johns Hopkins Medical Institutions, Baltimore, MD; and the Biomedical Imaging Research Institute, Department of Biomedical Sciences (D.D.) and Departments of Imaging and Medicine (D.S.B.), Cedars-Sinai Medical Center, Los Angeles, CA.
Diane M BeckerFrom the Johns Hopkins GeneSTAR Research Program, Department of Medicine (B.G.K., L.C.B., D.V., L.R.Y., R.Q., T.F.M., D.M.B.) and Department of Radiology (S.L.Z., E.K.F.), The Johns Hopkins Medical Institutions, Baltimore, MD; and the Biomedical Imaging Research Institute, Department of Biomedical Sciences (D.D.) and Departments of Imaging and Medicine (D.S.B.), Cedars-Sinai Medical Center, Los Angeles, CA.
Cedars-Sinai Medical Center · US

Funding

ZINC AND CA EDTA THERAPY OF PLUMBISMM01RR000052 · NCRR · JOHNS HOPKINS UNIVERSITY · PI MARSH, LAURA · 1985 to 2007
$37.3M
Coronary Disease Detection by Thalluim SPECT and Fast CTR01HL071025 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI BECKER, LEWIS C · 2003 to 2006
$2.6M
Nurse Model in Black Families at Risk for Heart DiseaseR01NR008153 · NINR · JOHNS HOPKINS UNIVERSITY · PI BECKER, DIANE M · 2002 to 2005
$2.2M
DETERMINANTS OF CORONARY DISEASE IN HIGH RISK FAMILIESR01HL059684 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI BECKER, LEWIS C · 1998 to 2001
$1.1M
Novel Technologies to Identify Preclinical Coronary Disease in High Risk FamiliesRC1HL099747 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI BECKER, LEWIS C · 2009 to 2010
$1.0M
Genetic Determinants of Coronary Artery Calcification in High-Risk FamiliesK23HL094747 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI KRAL, BRIAN G · 2009 to 2013
$696k
NCRR NIH HHS M01 RR000052NCRR NIH HHS M01-RR000052NHLBI NIH HHS K23 HL094747NHLBI NIH HHS K23HL094747NHLBI NIH HHS R01 HL059684NHLBI NIH HHS R01 HL071025NHLBI NIH HHS R01HL071025NHLBI NIH HHS R01HL59684,NHLBI NIH HHS RC1 HL099747NHLBI NIH HHS RC1HL099747NINR NIH HHS R01 NR008153NINR NIH HHS R01NR08153
6 · The paper itself

Abstract

backgroundAlthough age and sex distributions of calcified coronary plaque have been well described in the general population, noncalcified plaque (NCP) distributions remain unknown. This is important because NCP is a putative precursor for clinical coronary artery disease and could serve as a sentinel for aggressive primary prevention, especially in high-risk populations. We examined the distributions of NCP and calcified coronary plaque in healthy 30- to 74-year-old individuals from families with early onset coronary artery disease. METHODS AND

resultsParticipants in the GeneSTAR family study (N=805), mean age 51.1±10.8 years, 56% women, were screened for coronary artery disease risk factors and coronary plaque using dual-source computed tomographic angiography. Plaque volumes (mm(3)) were quantified using a validated automated method. The prevalence of coronary plaque was 57.8% in men and 35.8% in women (P<0.0001). NCP volume increased with age (P<0.001) and was higher in men than women (P<0.001). Although NCP, as a percentage of total plaque, was inversely related to age (P<0.01), NCP accounted for most of the total plaque volume at all ages, especially in men and women <55 years (>70% and >80%, respectively). Higher Framingham risk was associated with the number of affected vessels (P<0.01), but 44% of men and 20.8% of women considered intermediate risk had left main and 3-vessel disease involvement.

conclusionsThe majority of coronary plaque was noncalcified, particularly in younger individuals. These findings support the importance of assessing family history and suggest that early primary prevention interventions may be warranted at younger ages in families with early onset coronary artery disease.

Indexed as

Family HealthAdultAgedAge FactorsAge of OnsetCoronary AngiographyCoronary Artery DiseaseFemaleHumansMaleMiddle AgedPlaque, AtheroscleroticPrevalenceProspective StudiesRisk FactorsSex Factorsasymptomatic diseasesatherosclerosismultidetector computed tomography

Identifiers

PMID24577355
PMCPMC4419782
OpenAlexW2127637905

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.