ArticleEye (London, England)2014
Changes in cytokines in tears after endoscopic endonasal dacryocystorhinostomy for primary acquired nasolacrimal duct obstruction.
Article in Eye (London, England), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- The Use of Stents in Children with Nasolacrimal Duct Obstruction Requiring Surgical Intervention: A Systematic Review.International journal of environmental research and public health · 2020Pooled it
- To compare the efficacy of endoscopic dacryocystorhinostomy and external dacryocystorhinostomy in the treatment of chronic dacryocystitis based on propensity score matching.BMC ophthalmology · 2026Article
- Proteome Analysis of Nasolacrimal Duct Lavage Fluid in Patients with Primary Acquired Nasolacrimal Duct Obstruction.International journal of molecular sciences · 2026Article
- Impact of external dacryocystorhinostomy on corneal aberrations and optical quality in primary acquired nasolacrimal duct obstruction.International ophthalmology · 2025Article
- Tear Proteome Analysis with Patients with Primary Nasolacrimal Duct Obstruction.International journal of molecular sciences · 2025Article
- Changes in tear cytokine and lactoferrin levels in postmenopausal women with primary acquired nasolacrimal duct obstruction complicated with obstructed meibomian gland dysfunction.BMC ophthalmology · 2025Article
- A lacrimal drainage pathway disease-associated keratopathy (LDAK) case with non-infectious endophthalmitis.American journal of ophthalmology case reports · 2024Article
- Proportion and characteristics of lacrimal drainage pathway disease and keratopathy in non-infectious corneal perforation using lacrimal syringing test.Scientific reports · 2023Article
- Ocular injury progression and cornea histopathology from chloropicrin vapor exposure: Relevant clinical biomarkers in mice.Experimental eye research · 2023Article
- Clinical characteristics of lacrimal drainage pathway disease-associated keratopathy.BMC ophthalmology · 2022Article
- Detection & analysis of inflammatory cytokines in tears of patients with lacrimal duct obstruction.The Indian journal of medical research · 2021Article
- Tear protein analysis in patients with primary acquired nasolacrimal duct obstruction treated with lacrimal passage intubation.Japanese journal of ophthalmology · 2021Article
- Modified ocular surface disease index as a screening criteria for dry eye syndrome presenting after successful dacryocystorhinostomy.PloS one · 2021Article
- Evaluation of Tear Film Lipid Layer Thickness Measurements Obtained Using an Ocular Surface Interferometer in Nasolacrimal Duct Obstruction Patients.Korean journal of ophthalmology : KJO · 2018Article
- Conjunctival cytologic features in patients with unilateral primary acquired nasolacrimal duct obstruction.International ophthalmology · 2018Article
- Kinetic Profiles of Inflammatory Mediators in the Conjunctival Sac Fluid of Patients upon Photorefractive Keratectomy.Mediators of inflammation · 2015Article
- Human Serum Eye Drops in Eye Alterations: An Insight and a Critical Analysis.Journal of ophthalmology · 2015Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeWe attempted to compare the cytokine composition of tears between primary acquired nasolacrimal duct (NLD) obstruction and normal controls. We investigated the changes in cytokines in tears after endoscopic endonasal dacryocystorhinostomy (DCR). PATIENTS AND
methodsEighteen patients underwent endonasal DCR, with seven patients undergoing bilateral DCR, resulting in twenty-five DCRs in total. Eleven contralateral un-operated eyes were used as normal controls. Silicone stents were removed 3 months after surgery. Tear samples were collected from all eyes before surgery, and at 1 month, 2 months, 3 months, and 4 months after surgery. The level of interleukin (IL)-1β, IL-2, IL-6, IL-10, transforming growth factor (TGF)-β2, fibroblast growth factor (FGF)-2, and vascular endothelial growth factor (VEGF) in the tears was measured.
resultsThe concentrations of IL-2, IL-6, IL-10, VEGF, and FGF-2 were significantly higher in eyes with NLD obstruction than controls before surgery (P=0.006, 0.018, 0.002, 0.048, and 0.039, respectively). Most inflammatory cytokines (IL-1β, IL-2, IL-6, VEGF, and FGF-2) were higher in the tears of the DCR group compared with the controls during the postoperative follow-up, but then rapidly decreased to the level of the controls after removal of the silicone stent. The recurred eyes showed a higher level of TGF-β2 and FGF-2 in tears compared with the eyes that showed good surgical results (P<0.005 and <0.005, respectively).
conclusionThe tear levels of inflammatory cytokines were higher in eyes with NLD obstruction than controls. The changes in cytokine level during the postoperative period showed the importance of cytokine analysis in understanding wound healing after DCR.
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