ReviewThe Journal of biological chemistry2014
Hormonal signaling in the gut.
Review in The Journal of biological chemistry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 69 citations in OpenAlex.
- Anti-obesity and lipid-lowering effects of mountain caviar extract and its principal saponin momordin Ic via delayed gastric emptying and GLP-1 secretion independent of energy expenditure.Journal of natural medicines · 2026Article
- High cholesterol absorption efficiency enhances proatherogenic properties of low-density lipoprotein particles.Journal of internal medicine · 2026Article
- Research Advances of Neuroregulatory Effects of Dietary Polyphenols on Obesity Complications.Nutrients · 2026Review
- Metabolic Disorders, the Microbiome as an Endocrine Organ, and Their Relations with Obesity: A Literature Review.Journal of personalized medicine · 2023Review
- Applications of Enteroendocrine Cells (EECs) Hormone: Applicability on Feed Intake and Nutrient Absorption in Chickens.Animals : an open access journal from MDPI · 2023Review
- New biofunctional effects of oleanane-type triterpene saponins.Journal of natural medicines · 2023Review
- Gastrointestinal organoids in the study of viral infections.American journal of physiology. Gastrointestinal and liver physiology · 2023Review
- Anatomical, histochemical, and immunohistochemical observations on the gastrointestinal tract of Gallinula chloropus (Aves: Rallidae).BMC zoology · 2022Article
- Gastrointestinal pathophysiology during endurance exercise: endocrine, microbiome, and nutritional influences.European journal of applied physiology · 2021Review
- Sucralose and Cardiometabolic Health: Current Understanding from Receptors to Clinical Investigations.Advances in nutrition (Bethesda, Md.) · 2021Review
- The metabolic impact of small intestinal nutrient sensing.Nature communications · 2021Review
- Glucose transporters in the small intestine in health and disease.Pflugers Archiv : European journal of physiology · 2020Review
- The Gastrointestinal Tract as Prime Site for Cardiometabolic Protection by Dietary Polyphenols.Advances in nutrition (Bethesda, Md.) · 2019Review
- Unique Gene Expression Signatures in the Intestinal Mucosa and Organoids Derived from Germ-Free and Monoassociated Mice.International journal of molecular sciences · 2019Article
- A Glucagon-Like Peptide-1 Receptor Agonist Lowers Weight by Modulating the Structure of Gut Microbiota.Frontiers in endocrinology · 2018Article
- Anxiety, Depression, and the Microbiome: A Role for Gut Peptides.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2018Review
- Impact of Intestinal Peptides on the Enteric Nervous System: Novel Approaches to Control Glucose Metabolism and Food Intake.Frontiers in endocrinology · 2018Review
- The Role of GLP-1 in the Metabolic Success of Bariatric Surgery.Endocrinology · 2017Review
- Modulation of receptor signaling by metabolic environment.The American journal of clinical nutrition · 2017Article
- Immunologic impact of the intestine in metabolic disease.The Journal of clinical investigation · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
The gut is anatomically positioned to play a critical role in the regulation of metabolic homeostasis, providing negative feedback via nutrient sensing and local hormonal signaling. Gut hormones, such as cholecystokinin (CCK) and glucagon-like peptide-1 (GLP-1), are released following a meal and act on local receptors to regulate glycemia via a neuronal gut-brain axis. Additionally, jejunal nutrient sensing and leptin action are demonstrated to suppress glucose production, and both are required for the rapid antidiabetic effect of duodenal jejunal bypass surgery. Strategies aimed at targeting local gut hormonal signaling pathways may prove to be efficacious therapeutic options to improve glucose control in diabetes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.