ArticleThe Pediatric infectious disease journal2014
Multicenter study of viral etiology and relapse in hospitalized children with bronchiolitis.
Article in The Pediatric infectious disease journal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 55 citations in OpenAlex.
- Magnesium sulphate for treating acute bronchiolitis in children up to two years of age.The Cochrane database of systematic reviews · 2020Pooled it
- Transcriptome assists prognosis of disease severity in respiratory syncytial virus infected infants.Scientific reports · 2016Trial
- Hospitalisations for respiratory tract infections in preterm and term born children aged 1-5 years before, during and after COVID-19 control measures: an interrupted time-series analysis.BMJ paediatrics open · 2026Article
- Early Risk Assessment and Recognition of Allergies in Children: Rationale, Methodology, and Proposed Algorithms.Allergy · 2026Review
- Article
- Factors associated with mild bronchiolitis in young infants.Journal of the American College of Emergency Physicians open · 2023Article
- Realising respiratory microbiomic meta-analyses: time for a standardised framework.Microbiome · 2023Article
- Impact of RSV test positivity, patient characteristics, and treatment characteristics on the cost of hospitalization for acute bronchiolitis in a French university medical center (2010-2015).Frontiers in pediatrics · 2023Article
- The Differences Between RSV and no RSV Acute Bronchiolitis in Hospitalized Infants: A Cross-Sectional Study.Global pediatric health · 2022Article
- Clinico-virological Profile, Intensive Care Needs, and Outcome of Infants with Acute Viral Bronchiolitis: A Prospective Observational Study.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2021Article
- Epidemiology of Bronchiolitis in Hospitalized Infants at Tawam Hospital, Al Ain, United Arab Emirates.The open respiratory medicine journal · 2021Article
- Innate IFN-lambda responses to dsRNA in the human infant airway epithelium and clinical regulatory factors during viral respiratory infections in early life.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2020Article
- Bedside clinical assessment predicts recurrence after hospitalization due to viral lower respiratory tract infection in young children.Journal of investigative medicine : the official publication of the American Federation for Clinical Research · 2020Article
- Phenotypical Sub-setting of the First Episode of Severe Viral Respiratory Infection Based on Clinical Assessment and Underlying Airway Disease: A Pilot Study.Frontiers in pediatrics · 2020Article
- Nasal Cytokine Profiles of Patients Hospitalised with Respiratory Wheeze Associated with Rhinovirus C.Viruses · 2019Article
- Bronchiolitis Admissions in a Lebanese Tertiary Medical Center: A 10 Years' Experience.Frontiers in pediatrics · 2019Article
- Risk factors for bronchiolitis severity: A retrospective review of patients admitted to the university hospital from central region of Slovenia.Influenza and other respiratory viruses · 2018Article
- Respiratory-syncytial-virus- and rhinovirus-related bronchiolitis in children aged <2 years in an English district general hospital.The Journal of hospital infection · 2017Article
- Rhinovirus species and clinical characteristics in the first wheezing episode in children.Journal of medical virology · 2016Article
- Association of nasopharyngeal microbiota profiles with bronchiolitis severity in infants hospitalised for bronchiolitis.The European respiratory journal · 2016Article
Corrections and comments
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Authors and funding
10 authors at 7 institutions in 1 country.
Funding
Abstract
backgroundIt is unclear whether the infectious etiology of severe bronchiolitis affects short-term outcomes, such as posthospitalization relapse. We tested the hypothesis that children hospitalized with rhinovirus (RV) bronchiolitis, either as a sole pathogen or in combination with respiratory syncytial virus (RSV), are at increased risk of relapse.
methodsWe performed a 16-center, prospective cohort study of hospitalized children age <2 years with bronchiolitis. During the winters of 2007-2010, researchers collected clinical data and nasopharyngeal aspirates from study participants; the aspirates were tested using real-time polymerase chain reaction. The primary outcome was bronchiolitis relapse (urgent bronchiolitis visit or scheduled visit at which additions to the bronchiolitis medications were made) during the 2 weeks after hospital discharge.
resultsAmong 1836 enrolled children with 2-week, follow-up data, the median age was 4 months and 60% were male. Overall, 48% had sole RSV infection, 8% had sole RV infection, and 13% had RSV/RV coinfection. Compared with children with sole RSV infection, and adjusting for 10 demographic and clinical characteristics and clustering of patients within hospitals, children with sole RV infection did not differ in their likelihood of relapse (odds ratio: 0.99; 95% confidence interval: 0.52-1.90; P = 0.98), whereas those with RSV/RV coinfection were more likely to have relapse (odds ratio: 1.54; 95% confidence interval: 1.03-2.30; P = 0.03).
conclusionsIn this prospective, multicenter, multiyear study of children hospitalized with bronchiolitis, we found that RSV/RV coinfection was independently associated with a higher likelihood of bronchiolitis relapse. Present data support the concept that the infectious etiology of severe bronchiolitis affects short-term outcomes.
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Registered trials
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