ArticleThe Journal of infection2014
Unique reassortant of influenza A(H7N9) virus associated with severe disease emerging in Hong Kong.
Article in The Journal of infection, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 45 citations in OpenAlex.
- Enhanced replication of a contemporary avian influenza A H9N2 virus in human respiratory organoids.Emerging microbes & infections · 2025Article
- Antigenicity and genetic properties of an Eurasian avian-like H1N1 swine influenza virus in Jiangsu Province, China.Biosafety and health · 2024Article
- Human neutralizing antibodies target a conserved lateral patch on H7N9 hemagglutinin head.Nature communications · 2024Article
- Allosteric Neutralization by Human H7N9 Antibodies.Research square · 2023Article
- The evolution and future of influenza pandemic preparedness.Experimental & molecular medicine · 2021Review
- Genetic Characterization of Avian Influenza A (H11N9) Virus Isolated from Mandarin Ducks in South Korea in 2018.Viruses · 2020Article
- Adequacy of public health communications on H7N9 and MERS in Singapore: insights from a community based cross-sectional study.BMC public health · 2018Article
- Low population serum microneutralization antibody titer against the predominating influenza A(H3N2) N121K virus during the severe influenza summer peak of Hong Kong in 2017.Emerging microbes & infections · 2018Article
- First genome report and analysis of chicken H7N9 influenza viruses with poly-basic amino acids insertion in the hemagglutinin cleavage site.Scientific reports · 2017Article
- Additional molecular testing of saliva specimens improves the detection of respiratory viruses.Emerging microbes & infections · 2017Article
- Aberrant coagulation causes a hyper-inflammatory response in severe influenza pneumonia.Cellular & molecular immunology · 2016Review
- Residues in the PB2 and PA genes contribute to the pathogenicity of avian H7N3 influenza A virus in DBA/2 mice.Virology · 2016Article
- Article
- Prevalence and characteristics of hypoxic hepatitis in the largest single-centre cohort of avian influenza A(H7N9) virus-infected patients with severe liver impairment in the intensive care unit.Emerging microbes & infections · 2016Article
- Distinct Host Tropism Protein Signatures to Identify Possible Zoonotic Influenza A Viruses.PloS one · 2016Article
- A returning migrant worker with avian influenza A (H7N9) virus infection in Guizhou, China: a case report.Journal of medical case reports · 2015Article
- Cross-species transmission and emergence of novel viruses from birds.Current opinion in virology · 2015Review
- Characterization of influenza A (H7N9) viruses isolated from human cases imported into Taiwan.PloS one · 2015Article
- The K526R substitution in viral protein PB2 enhances the effects of E627K on influenza virus replication.Nature communications · 2014Article
- Continuous reassortments with local chicken H9N2 virus underlie the human-infecting influenza A (H7N9) virus in the new influenza season, Guangdong, China.Protein & cell · 2014Article
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveHuman infections caused by avian influenza virus A(H7N9) re-emerged in late 2013. We reported the first Hong Kong patient without risk factors for severe A(H7N9) disease.
methodsDirect sequencing was performed on the endotracheal aspirate collected from a 36-year-old female with history of poultry contact. Bioinformatic analysis was performed to compare the current strain and previous A(H7N9) isolates.
resultsThe influenza A/Hong Kong/470129/2013 virus strain was detected in a patient with acute respiratory distress syndrome, deranged liver function and coagulation profile, cytopenia, and rhabdomyolysis. The HA, NA and MP genes of A/Hong Kong/470129/2013 cluster with those of other human A(H7N9) strains. The PB1, PB2 and NS genes are most closely related to those of A/Guangdong/1/2013 strain identified in August 2013, but are distinct from those of other human and avian A(H7N9) strains. The other internal genes NP and PA genes are more closely related to those of non-A(H7N9) avian influenza A viruses. A unique PA L336M mutation, associated with increased polymerase activity, was found. The patient required salvage by extracorporeal membrane oxygenation.
conclusionsThe A/Hong Kong/470129/2013 virus is a novel reassortant derived from A/Guangdong/1/2013 virus. The unique mutation PA L336M may enhance viral replication and therefore disease severity.
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