Trial reportAmerican heart journal2014
DETermination of the role of OXygen in suspected Acute Myocardial Infarction trial.
Trial report in American heart journal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It reports registered trial NCT02286544. Cited by 17 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effects of Oxygen Treatment on Mechanisms Involved in Ischemia-reperfusion Injury: A Single Center, Randomized, Controlled Pilot Study in Healthy Volunteers
DETermination of the Role of OXygen in Suspected Acute Myocardial Infarction (DETO2X-AMI) Based on the SWEDEHEART Registry
Determination of the Role of Oxygen on Mechanisms Involved in Ischemia-reperfusion Injury in Suspected Acute Myocardial Infarction by Biomarkers. A Sub Study to the DETO2X-AMI Trial.
Who cites it
17 citing papers in PubMed, 5 syntheses or guidelines pooled it, 73 citations in OpenAlex.
- Prodromal Symptoms of Acute Myocardial Infarction in Women: A Systematic Review of Current Evidence.Nursing open · 2025Pooled it
- Registry-based randomised controlled trials: conduct, advantages and challenges-a systematic review.Trials · 2024Pooled it
- Clinical Practice Guideline of Integrative Chinese and Western Medicine for Acute Myocardial Infarction.Chinese journal of integrative medicine · 2020Guideline
- Guideline
- Oxygen therapy for acute myocardial infarction.The Cochrane database of systematic reviews · 2016Pooled it
- Avoiding Routine Oxygen Therapy in Patients With Myocardial Infarction Saves Significant Expenditure for the Health Care System-Insights From the Randomized DETO2X-AMI Trial.Frontiers in public health · 2021Trial
- Trial
- Routine Oxygen Therapy Does Not Improve Health-Related Quality of Life in Patients With Acute Myocardial Infarction-Insights From the Randomized DETO2X-AMI Trial.Frontiers in cardiovascular medicine · 2021Article
- High time to omit oxygen therapy in ST elevation myocardial infarction.BMC emergency medicine · 2018Article
- [Acute coronary syndrome in older people].Zeitschrift fur Gerontologie und Geriatrie · 2018Article
- Efficient design of clinical trials and epidemiological research: is it possible?Nature reviews. Cardiology · 2017Review
- [Oxygen therapy in acute myocardial infarction].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2017Article
- Harmful Effects of Hyperoxia in Postcardiac Arrest, Sepsis, Traumatic Brain Injury, or Stroke: The Importance of Individualized Oxygen Therapy in Critically Ill Patients.Canadian respiratory journal · 2017Review
- Chest Pain of Suspected Cardiac Origin: Current Evidence-based Recommendations for Prehospital Care.The western journal of emergency medicine · 2015Review
- Registry-based randomized clinical trials--a new clinical trial paradigm.Nature reviews. Cardiology · 2015Review
- Article
- Clinical disease registries in acute myocardial infarction.World journal of cardiology · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe use of supplemental oxygen in the setting of suspected acute myocardial infarction (AMI) is recommended in international treatment guidelines and established in prehospital and hospital clinical routine throughout the world. However, to date there is no conclusive evidence from adequately designed and powered trials supporting this practice. Existing data are conflicting and fail to clarify the role of supplemental oxygen in AMI.
methodsA total of 6,600 normoxemic (oxygen saturation [SpO2] ≥90%) patients with suspected AMI will be randomly assigned to either supplemental oxygen 6 L/min delivered by Oxymask (MedCore Sweden AB, Kista, Sweden) for 6 to 12 hours in the treatment group or room air in the control group. Patient inclusion and randomization will take place at first medical contact, either before hospital admission or at the emergency department. The Swedish Web-system for Enhancement and Development of Evidence-based care in Heart disease Evaluated According to Recommended Therapies registry will be used for online randomization, allowing inclusion of a broad population of all-comers. Follow-up will be carried out in nationwide health registries and Swedish Web-system for Enhancement and Development of Evidence-based care in Heart disease Evaluated According to Recommended Therapies. The primary objective is to evaluate whether oxygen reduces 1-year all-cause mortality. Secondary end points include 30-day mortality, major adverse cardiac events, and health economy. Prespecified subgroups include patients with confirmed AMI and certain risk groups. In a 3-month pilot study, the study concept was found to be safe and feasible.
conclusionThe need to clarify the uncertainty of the role of supplemental oxygen therapy in the setting of suspected AMI is urgent. The DETO2X-AMI trial is designed and powered to address this important issue and may have a direct impact on future recommendations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.