ArticleBMC systems biology2014
Extinction, coexistence, and localized patterns of a bacterial population with contact-dependent inhibition.
Article in BMC systems biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 18 citations in OpenAlex.
- Neisseria subflava Type 6 Secretion System competition with bacterial and fungal species.Applied microbiology and biotechnology · 2026Article
- Agent-Based Modeling of Microbial Communities.ACS synthetic biology · 2022Review
- Nonlinear self-organized population dynamics induced by external selective nonlocal processes.Communications in nonlinear science & numerical simulation · 2021Article
- Contact-Dependent Growth Inhibition in Bacteria: Do Not Get Too Close!International journal of molecular sciences · 2020Review
- Spatial Ecology of the Human Tongue Dorsum Microbiome.Cell reports · 2020Article
- Formation of phage lysis patterns and implications on co-propagation of phages and motile host bacteria.PLoS computational biology · 2020Article
- Spatial Organization of Expanding Bacterial Colonies Is Affected by Contact-Dependent Growth Inhibition.Current biology : CB · 2019Article
- Coexistence and Pattern Formation in Bacterial Mixtures with Contact-Dependent Killing.Biophysical journal · 2018Article
- Mechanism of Kin-Discriminatory Demarcation Line Formation between Colonies of Swarming Bacteria.Biophysical journal · 2017Article
- Population-Dynamic Modeling of Bacterial Horizontal Gene Transfer by Natural Transformation.Biophysical journal · 2016Article
- Bacterial Communities: Interactions to Scale.Frontiers in microbiology · 2016Review
- Bacterial social interactions drive the emergence of differential spatial colony structures.BMC systems biology · 2015Article
- Microbial activities and intestinal homeostasis: A delicate balance between health and disease.Cellular and molecular gastroenterology and hepatology · 2015Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundContact-dependent inhibition (CDI) has been recently revealed as an intriguing but ubiquitous mechanism for bacterial competition in which a species injects toxins into its competitors through direct physical contact for growth suppression. Although the molecular and genetic aspects of CDI systems are being increasingly explored, a quantitative and systematic picture of how CDI systems benefit population competition and hence alter corresponding competition outcomes is not well elucidated.
resultsBy constructing a mathematical model for a population consisting of CDI+ and CDI- species, we have systematically investigated the dynamics and possible outcomes of population competition. In the well-mixed case, we found that the two species are mutually exclusive: Competition always results in extinction for one of the two species, with the winner determined by the tradeoff between the competitive benefit of the CDI+ species and its growth disadvantage from increased metabolic burden. Initial conditions in certain circumstances can also alter the outcome of competition. In the spatial case, in addition to exclusive extinction, coexistence and localized patterns may emerge from population competition. For spatial coexistence, population diffusion is also important in influencing the outcome. Using a set of illustrative examples, we further showed that our results hold true when the competition of the population is extended from one to two dimensional space.
conclusionsWe have revealed that the competition of a population with CDI can produce diverse patterns, including extinction, coexistence, and localized aggregation. The emergence, relative abundance, and characteristic features of these patterns are collectively determined by the competitive benefit of CDI and its growth disadvantage for a given rate of population diffusion. Thus, this study provides a systematic and statistical view of CDI-based bacterial population competition, expanding the spectrum of our knowledge about CDI systems and possibly facilitating new experimental tests for a deeper understanding of bacterial interactions.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.