ArticleAlcoholism, clinical and experimental research2014
Poor autonomic nervous system functioning during sleep in recently detoxified alcohol-dependent men and women.
Article in Alcoholism, clinical and experimental research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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Who cites it
9 citing papers in PubMed, 17 citations in OpenAlex.
- Sleep alterations in substance use disorders: a systematic review and meta-analysis.EClinicalMedicine · 2026Article
- Evoked K-complexes and altered interaction between the central and autonomic nervous systems during sleep in alcohol use disorder.Alcohol (Fayetteville, N.Y.) · 2020Article
- The effect of alcohol withdrawal syndrome severity on sleep, brain and cognition.Brain communications · 2020Article
- Sleep and Alcohol Use in Women.Alcohol research : current reviews · 2020Review
- Cardiorespiratory Fitness Predicts Greater Vagal Autonomic Activity in Drug Users Under Stress.Substance abuse : research and treatment · 2019Article
- Improving cerebral oxygenation, cognition and autonomic nervous system control of a chronic alcohol abuser through a three-month running program.Addictive behaviors reports · 2017Article
- Alcohol Dependence and Its Relationship With Insomnia and Other Sleep Disorders.Alcoholism, clinical and experimental research · 2016Review
- Cardiac autonomic function during sleep: effects of alcohol dependence and evidence of partial recovery with abstinence.Alcohol (Fayetteville, N.Y.) · 2015Article
- Sleep and substance use disorders: an update.Current psychiatry reports · 2014Review
Corrections and comments
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Authors and funding
6 authors at 5 institutions in 3 countries.
Funding
Abstract
backgroundAlcoholism is considered an important risk factor for cardiovascular (CV) disease. Autonomic nervous system (ANS) function is a major indicator of CV health. Sleep is a suitable model to investigate ANS activity free from wake-related confounders. We investigated nighttime ANS functioning, and the relation between ANS activity and severity of alcohol dependence in chronic alcoholism.
methodsFourteen recently abstaining alcoholics (age: 42.0 ± 9.0 years, 7 women) and 16 age- and sex-matched controls (age: 45.2 ± 9.1 years, 8 women) underwent a night of standard clinical polysomnography, including electrocardiographic recording. Time- and frequency-domain spectral analysis of heart rate variability (HRV) was performed across hours of the night and during artifact-free epochs of stable sleep and wakefulness (presleep wakefulness, rapid-eye-movement [REM], and non-REM sleep).
resultsAlcoholics had a poorer subjective and objective sleep quality compared to controls. Across the night, alcoholic men and women had elevated heart rate, reduced total HRV, that is, lower standard deviation of normal-to-normal interbeat intervals, and reduced high frequency (HF) activity (assessed by the HF power and by the square root of the mean squared of successive heart period differences). This ANS pattern was most apparent at the beginning of the night. None of the ANS measures was associated with lifetime alcohol consumption or duration of alcohol dependence.
conclusionsOur results show that ANS functioning is disrupted during the night, even in undisturbed sleep periods, indicating poor CV functioning in recently detoxified alcohol-dependent men and women.
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