ArticleBMC pediatrics2014
Significance of hydrogen breath tests in children with suspected carbohydrate malabsorption.
Article in BMC pediatrics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- European guideline on indications, performance, and clinical impact of hydrogen and methane breath tests in adult and pediatric patients: European Association for Gastroenterology, Endoscopy and Nutrition, European Society of Neurogastroenterology and Motility, and European Society for Paediatric Gastroenterology Hepatology and Nutrition consensus.United European gastroenterology journal · 2022Guideline
- Influence of Measuring Circuit Parameters on the Characteristics of MIS-Capacitor Hydrogen Sensors.Sensors (Basel, Switzerland) · 2026Article
- Association of gastroesophageal reflux disease with small intestinal bacterial overgrowth: a case-control study.BMC gastroenterology · 2025Article
- Review
- Highly Sensitive and Selective Detection of Hydrogen Using Pd-Coated SnOSensors (Basel, Switzerland) · 2022Article
- Small Intestinal Bacterial Overgrowth in Subclinical Hypothyroidism of Pregnant Women.Frontiers in endocrinology · 2021Article
- Association of Differential Metabolites With Small Intestinal Microflora and Maternal Outcomes in Subclinical Hypothyroidism During Pregnancy.Frontiers in cellular and infection microbiology · 2021Article
- Development and validation of the paediatric Carbohydrate Perception Questionnaire (pCPQ), an instrument for the assessment of carbohydrate-induced gastrointestinal symptoms in the paediatric population.Neurogastroenterology and motility · 2020Article
- Methane breath tests and blood sugar tests in children with suspected carbohydrate malabsorption.Scientific reports · 2020Article
- Article
- 'Rapid transit' constipation in children: a possible genesis for irritable bowel syndrome.Pediatric surgery international · 2020Review
- Roles of Lactose and Fructose Malabsorption and Dietary Outcomes in Children Presenting with Chronic Abdominal Pain.Nutrients · 2019Article
- Fructose malabsorption in asymptomatic children and in patients with functional chronic abdominal pain: a prospective comparative study.European journal of pediatrics · 2019Observational
- Dietary exclusion of fructose and lactose after positive breath tests improved rapid-transit constipation in children.JGH open : an open access journal of gastroenterology and hepatology · 2018Article
- Intestinal Absorption of Fructose.Annual review of nutrition · 2018Review
- Hydrogen excretion in pediatric lactose malabsorbers: relation to symptoms and the dose of lactose.Archives of medical science : AMS · 2018Article
- Effects of fructose-containing sweeteners on fructose intestinal, hepatic, and oral bioavailability in dual-catheterized rats.PloS one · 2018Article
- A nutritional approach for managing irritable bowel syndrome.Current opinion in pediatrics · 2017Review
- Controversies and Recent Developments of the Low-FODMAP Diet.Gastroenterology & hepatology · 2017Article
- Nuclear transit study in children with chronic faecal soiling after Hirschsprung disease (HSCR) surgery has revealed a group with rapid proximal colonic treatment and possible adverse reactions to food.Pediatric surgery international · 2016Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHydrogen breath tests are noninvasive procedures frequently applied in the diagnostic workup of functional gastrointestinal disorders. Here, we review hydrogen breath test results and the occurrence of lactose, fructose and sorbitol malabsorption in pediatric patients; and determine the significance of the findings and the outcome of patients with carbohydrate malabsorption.
methodsWe included 206 children (88 male, 118 female, median age 10.7 years, range 3-18 years) with a total of 449 hydrogen breath tests (lactose, n = 161; fructose, n = 142; sorbitol, n = 146) into a retrospective analysis. Apart from test results, we documented symptoms, the therapeutic consequences of the test, the outcome and the overall satisfaction of the patients and families.
resultsIn total, 204 (46%) of all breath tests were positive. Long-term follow-up data could be collected from 118 patients. Of 79 patients (67%) who were put on a diet reduced in lactose, fructose and/or sorbitol, the majority (92%, n = 73) reported the diet to be strict and only 13% (n = 10) had no response to diet. Most families (96%, n = 113) were satisfied by the test and the therapy. There were only 21 tests (5%) with a borderline result because the criteria for a positive result were only partially met.
conclusionsHydrogen breath tests can be helpful in the evaluation of children with gastrointestinal symptoms including functional intestinal disorders. If applied for a variety of carbohydrates but only where indicated, around two-third of all children have positive results. The therapeutic consequences are successfully relieving symptoms in the vast majority of patients.
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