ArticleBioconjugate chemistry2014
Library synthesis, screening, and discovery of modified Zinc(II)-Bis(dipicolylamine) probe for enhanced molecular imaging of cell death.
Article in Bioconjugate chemistry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 32 citations in OpenAlex.
- Targeting the Phosphatidylserine-Immune Checkpoint with a Small-Molecule Maytansinoid Conjugate.Journal of medicinal chemistry · 2022Article
- Dendron-Functionalized Surface: Efficient Strategy for Enhancing the Capture of Microvesicles.iScience · 2019Article
- Time-lapse imaging of cell death in cell culture and whole living organisms using turn-on deep-red fluorescent probes.Journal of materials chemistry. B · 2018Article
- Non-Covalent Assembly Method that Simultaneously Endows a Liposome Surface with Targeting Ligands, Protective PEG Chains, and Deep-Red Fluorescence Reporter Groups.Chemistry (Weinheim an der Bergstrasse, Germany) · 2017Article
- Antiplasmodial activity of targeted zinc(II)-dipicolylamine complexes.Bioorganic & medicinal chemistry · 2017Article
- Preassembled Fluorescent Multivalent Probes for the Imaging of Anionic Membranes.Bioconjugate chemistry · 2017Article
- Engineered Zn(II)-Dipicolylamine-Gold Nanorod Provides Effective Prostate Cancer Treatment by Combining siRNA Delivery and Photothermal Therapy.Theranostics · 2017Article
- Imaging and therapeutic applications of zinc(ii)-dipicolylamine molecular probes for anionic biomembranes.Chemical communications (Cambridge, England) · 2016Review
- Zinc(II)-Dipicolylamine Coordination Complexes as Targeting and Chemotherapeutic Agents for Leishmania major.Antimicrobial agents and chemotherapy · 2016Article
- Phenoxide-Bridged Zinc(II)-Bis(dipicolylamine) Probes for Molecular Imaging of Cell Death.Bioconjugate chemistry · 2016Article
- Evaluation of [¹¹¹In]-labeled zinc-dipicolylamine tracers for SPECT imaging of bacterial infection.Molecular imaging and biology · 2015Article
- Smart molecules for imaging, sensing and health (SMITH).Beilstein journal of organic chemistry · 2015Review
- Chemically triggered release of 5-aminolevulinic acid from liposomes.RSC advances · 2014Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Zinc(II)-bis(dipicolylamine) (Zn-BDPA) coordination complexes selectively target the surfaces of dead and dying mammalian cells, and they have promise as molecular probes for imaging cell death. A necessary step toward eventual clinical imaging applications is the development of next-generation Zn-BDPA complexes with enhanced affinity for the cell death membrane biomarker, phosphatidylserine (PS). This study employed an iterative cycle of library synthesis and screening, using a novel rapid equilibrium dialysis assay, to discover a modified Zn-BDPA structure with high and selective affinity for vesicles containing PS. The lead structure was converted into a deep-red fluorescent probe and its targeting and imaging performance was compared with an unmodified control Zn-BDPA probe. The evaluation process included a series of FRET-based vesicle titration studies, cell microscopy experiments, and rat tumor biodistribution measurements. In all cases, the modified probe exhibited comparatively higher affinity and selectivity for the target membranes of dead and dying cells. The results show that this next-generation deep-red fluorescent Zn-BDPA probe is well suited for preclinical molecular imaging of cell death in cell cultures and animal models. Furthermore, it should be possible to substitute the deep-red fluorophore with alternative reporter groups that enable clinically useful, deep-tissue imaging modalities, such as MRI and nuclear imaging.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.