ArticleACS macro letters2013
Synthetic Enantiopure Carbohydrate Polymers that are Highly Soluble in Water and Noncytotoxic.
Article in ACS macro letters, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 39 citations in OpenAlex.
- Synthesis and characterization of carbohydrate-based biosurfactant mimetics.Carbohydrate research · 2022Article
- Beyond nylon 6: polyamidesChemical Society reviews · 2022Review
- Synthesis of bioactive (1→6)-β-glucose branched poly-amido-saccharides that stimulate and induce M1 polarization in macrophages.Nature communications · 2022Article
- Sulfated poly-amido-saccharides (sulPASs) are anticoagulantsChemical science · 2021Article
- A Synthetic Bioinspired Carbohydrate Polymer with Mucoadhesive Properties.Angewandte Chemie (International ed. in English) · 2020Article
- Synthetic Biomaterials from Metabolically Derived Synthons.Chemical reviews · 2016Review
- Overcoming Gene-Delivery Hurdles: Physiological Considerations for Nonviral Vectors.Trends in biotechnology · 2016Review
- Ternary nylon-3 copolymers as host-defense peptide mimics: beyond hydrophobic and cationic subunits.Journal of the American Chemical Society · 2014Article
- Carboxylated glucuronic poly-amido-saccharides as protein stabilizing agents.Journal of the American Chemical Society · 2014Article
- Synthesis of Hydrophobic Carbohydrate Polymers and Their Formation of Thermotropic Liquid Crystalline Phases.ACS macro letters · 2014Article
- Structure-activity relationships among antifungal nylon-3 polymers: identification of materials active against drug-resistant strains of Candida albicans.Journal of the American Chemical Society · 2014Article
- Tuning the biological activity profile of antibacterial polymers via subunit substitution pattern.Journal of the American Chemical Society · 2014Article
- Synthesis of Bioinspired Carbohydrate Amphiphiles that Promote and Inhibit Biofilms.Chemical science · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The first synthesis of poly-amido-saccharides (PASs) from a galactose(gal)-derived β-lactam sugar monomer is reported. The polymers are prepared using a controlled anionic ring-opening polymerization and characterized by NMR, optical rotation, IR, and GPC. Galactose-derived PASs display high solubility in aqueous solutions and are noncytotoxic to HepG2, CHO, and HeLa cell lines. To evaluate whether gal-derived PASs are recognized by the gal-specific lectin present on human hepatocytes, cellular uptake of rhodamine-labeled polymers is assessed using flow cytometry and fluorescence microscopy. Based on these results, the polymers are taken into cells via endocytosis that is not dependent on the gal-specific receptor on hepatocytes. Neutral, hydrophilic polymers, such as gal-derived PASs, are desirable materials for a range of biomedical applications, such as drug delivery, surface passivation, and hydrogel formation.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.