ArticleBiomedical optics express2014
Non-invasive fluorescence imaging under ambient light conditions using a modulated ICCD and laser diode.
Article in Biomedical optics express, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 25 citations in OpenAlex.
- Spatio-temporally modulated fluorescence imager for intraoperative nerve identification.Journal of biomedical optics · 2026Article
- Standardizing clinical trials in near-infrared fluorescence imaging: a workflow and regulatory framework proposal.Npj imaging · 2026Review
- Optical and Optoacoustic Imaging.Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer · 2026Review
- Periodic Light Modulations for Low-Cost Wide-Field Imaging of Luminescence Kinetics Under Ambient Light.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- State of the art medical devices for fluorescence-guided surgery (FGS): technical review and future developments.Surgical endoscopy · 2024Review
- Impact of Surgical Lights on the Performance of Fluorescence-Guided Surgery Systems: A Pilot Study.Animals : an open access journal from MDPI · 2023Article
- Dynamic Contrast for Plant Phenotyping.ACS omega · 2020Article
- Perspective review of what is needed for molecular-specific fluorescence-guided surgery.Journal of biomedical optics · 2018Review
- Macroscale fluorescence imaging against autofluorescence under ambient light.Light, science & applications · 2018Article
- Quantitative assessment of Cerenkov luminescence for radioguided brain tumor resection surgery.Physics in medicine and biology · 2017Article
- Optimization of fluorescent imaging in the operating room through pulsed acquisition and gating to ambient background cycling.Biomedical optics express · 2017Article
- Review of fluorescence guided surgery systems: identification of key performance capabilities beyond indocyanine green imaging.Journal of biomedical optics · 2016Review
- Near-Infrared Fluorescence-Enhanced Optical Tomography.BioMed research international · 2016Review
- Single camera imaging system for color and near-infrared fluorescence image guided surgery.Biomedical optics express · 2014Article
- Engineering light-emitting diode surgical light for near-infrared fluorescence image-guided surgical systems.Journal of biomedical optics · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
One limitation of fluorescence molecular imaging that can limit clinical implementation and hamper small animal imaging is the inability to eliminate ambient light. Herein, we demonstrate the ability to conduct rapid non-invasive, far-red and near-infrared fluorescence imaging in living animals and a phantom under ambient light conditions using a modulated image intensified CCD (ICCD) and a laser diode operated in homodyne detection. By mapping AC amplitude from three planar images at varying phase delays, we show improvement in target-to-background ratios (TBR) and reasonable signal-to-noise ratios (SNR) over continuous wave measurements. The rapid approach can be used to accurately collect fluorescence in situations where ambient light cannot be spectrally conditioned or controlled, such as in the case of fluorescent molecular image-guided surgery.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.