Evidence map›Paper›PMID 24575296›Full record

ReviewBoneKEy reports2013

Is there a specific fracture 'cascade'?

L Joseph Melton, Shreyasee Amin

Abstract readReview
In one paragraph

Review in BoneKEy reports, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Observational
  4. Article
  5. History of Previous Fracture and Imminent Fracture Risk in Swedish Women Aged 55 to 90 Years Presenting With a Fragility Fracture.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2020
    Observational
  6. Article
  7. Review
  8. A Guide to Improving the Care of Patients with Fragility Fractures, Edition 2.Geriatric orthopaedic surgery & rehabilitation · 2015
    Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

L Joseph MeltonDivision of Epidemiology, Department of Health Sciences Research, Mayo Clinic , Rochester, MN, USA.
Shreyasee AminDivision of Epidemiology, Department of Health Sciences Research, Mayo Clinic , Rochester, MN, USA ; Division of Rheumatology, Department of Internal Medicine, Mayo Clinic , Rochester, MN, USA.
Mayo Clinic in Arizona · USMayo Clinic in Florida · US

Funding

SEX STEROIDS, GROWTH FACTORS, &BONE CELL FUNCTIONP01AG004875 · NIA · MAYO CLINIC ROCHESTER · PI KHOSLA, SUNDEEP · 1985 to 2019
$30.8M
EPIDEMIOLOGY OF AGE-RELATED BONE LOSS, &FRACTURESR01AR027065 · NIAMS · MAYO CLINIC ROCHESTER · PI AMIN, SHREYASEE, KHOSLA, SUNDEEP · 1986 to 2020
$14.9M
Rochester Epidemiology ProjectR01AG034676 · NIA · MAYO CLINIC ROCHESTER · PI ROCCA, WALTER A, ST SAUVER, JENNIFER LYNN · 2010 to 2019
$9.5M
NIAMS NIH HHS R01 AR027065NIA NIH HHS P01 AG004875NIA NIH HHS R01 AG034676
6 · The paper itself

Abstract

Different kinds of epidemiologic data provide varying views of the relationships among the main osteoporotic fractures. Descriptive incidence data indicate that distal forearm fractures typically occur earlier than vertebral fractures that, in turn, precede hip fractures late in life. In addition, relative risk estimates document the fact that one osteoporotic fracture increases the risk of subsequent ones. These two observations support the notion of a 'fracture cascade' and justify the recent emphasis on secondary prevention, that is, more aggressive treatment of patients presenting with a fracture in order to prevent recurrences. However, the absolute risk of a subsequent fracture given an initial one is modest, and the degree to which the second fracture can be attributed to the first one is unclear. Moreover, the osteoporotic fractures encountered in the majority of patients are the first one experienced, and even these initial fractures lead to substantial morbidity and cost. These latter points reemphasize the importance of primary prevention, that is, the management of bone loss and other risk factors to prevent the first fracture. Continued efforts are needed to refine risk assessment algorithms so that candidates for such fracture prophylaxis can be identified more accurately and efficiently.

Identifiers

PMID24575296
PMCPMC3935254
OpenAlexW2322233950

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.