ArticleARYA atherosclerosis2013
Clinical investigation of the acute effects of pomegranate juice on blood pressure and endothelial function in hypertensive individuals.
Article in ARYA atherosclerosis, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 64 citations in OpenAlex.
- A systematic review of the mechanisms of cardiovascular disease reduction by dietary flavonoids: the impact of anthocyanins on flow-mediated dilation and blood rheology.BMC nutrition · 2025Pooled it
- A Traditional Mouthwash (Punica granatum var pleniflora) for Controlling Gingivitis of Diabetic Patients: A Double-Blind Randomized Controlled Clinical Trial.Journal of evidence-based complementary & alternative medicine · 2017Trial
- Effects of Pomegranate Juice on Androgen Levels, Inflammation and Lipid Profile in Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2025Review
- An Overview of the Health Benefits, Extraction Methods and Improving the Properties of Pomegranate.Antioxidants (Basel, Switzerland) · 2023Review
- Nutrition Strategies Promoting Healthy Aging: From Improvement of Cardiovascular and Brain Health to Prevention of Age-Associated Diseases.Nutrients · 2022Review
- Antioxidant Properties and Beneficial Cardiovascular Effects of a Natural Extract of Pomegranate in Healthy Volunteers: A Randomized Preliminary Single-Blind Controlled Study.Antioxidants (Basel, Switzerland) · 2022Article
- Pharmacotherapeutic potential of pomegranate in age-related neurological disorders.Frontiers in aging neuroscience · 2022Review
- Therapeutic Potential of Pomegranate in Metabolic Disorders.Advances in experimental medicine and biology · 2021Review
- Therapeutic Effects ofJournal of nutrition and metabolism · 2021Review
- Gene Expression Changes in Pomegranate Peel Extract-Treated Triple-Negative Breast Cancer Cells.Reports of biochemistry & molecular biology · 2018Article
- Vasculoprotective Effects of Pomegranate (Frontiers in pharmacology · 2018Review
- Review
- Role of Dietary Components in Modulating Hypertension.Journal of clinical & experimental cardiology · 2016Article
- Effects of Concentrated Pomegranate Juice on Subclinical Inflammation and Cardiometabolic Risk Factors for Type 2 Diabetes: A Quasi-Experimental Study.International journal of endocrinology and metabolism · 2016Article
- Effects of Pomegranate Seed Oil on Metabolic State of Patients with Type 2 Diabetes Mellitus.International journal of preventive medicine · 2016Article
- Medicinal Plants for the Treatment of Acne Vulgaris: A Review of Recent Evidences.Jundishapur journal of microbiology · 2015Review
- Herbs with anti-lipid effects and their interactions with statins as a chemical anti- hyperlipidemia group drugs: A systematic review.ARYA atherosclerosis · 2015Review
- New concepts in nutraceuticals as alternative for pharmaceuticals.International journal of preventive medicine · 2014Review
- Atherosclerosis: process, indicators, risk factors and new hopes.International journal of preventive medicine · 2014Review
- Pomegranate seed oil protects against tacrolimus-induced toxicity in the heart and kidney by modulation of oxidative stress in rats.Avicenna journal of phytomedicineArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPomegranate juice (PJ) is rich in bioactive phytochemicals with antioxidant, and anti-inflammatory and cardioprotective functions. The present trial investigated the acute effects of PJ consumption on blood pressure and markers of endothelial function.
methodsIn this single-arm study, thirteen hypertensive men aged 39-68 years were recruited. Included subjects were assigned to natural PJ (150 ml/day) following a 12 hour fast. Systolic blood pressure (SBP), diastolic blood pressure (DBP), and flow-mediated dilation (FMD), along with serum concentrations of C-reactive protein (CRP), intracellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule 1 (VCAM-1), E-selectin and interleukin-6 (IL-6) were measured at baseline and 4-6 hours after PJ consumption.
resultsComparison of pre- vs. post-trial values revealed a significant reduction in both SBP (7%; P = 0.013) and DBP (6%; P < 0.010). However, changes in FMD (20%) as well as circulating levels of CRP, ICAM-1, VCAM-1, E-selectin, and IL-6 did not reach statistical significance (P = 0.172).
conclusionPJ has promising acute hypotensive properties. Consumption of PJ could be considered in the context of both dietary and pharmacological interventions for hypertension.
Indexed as
Identifiers
24575134PMC3933059W1548296124What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.