Evidence map›Paper›PMID 24575113›Full record

ArticleDementia and geriatric cognitive disorders extra2014

Association between the COMTVal158Met Genotype and Alzheimer's Disease in the Han Chinese Population.

Yong Ji, Zhihong Shi, Mengyuan Liu, Shuai Liu, Shuling Liu, Jinhuan Wang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Dementia and geriatric cognitive disorders extra, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Yong JiKey Laboratory of Cerebral Vascular Disease and Neurodegenerative Disease, Tianjin, China ; Department of Neurology, Tianjin Huanhu Hospital, Tianjin, China.
Zhihong ShiKey Laboratory of Cerebral Vascular Disease and Neurodegenerative Disease, Tianjin, China ; Department of Neurology, Tianjin Huanhu Hospital, Tianjin, China.
Mengyuan LiuKey Laboratory of Cerebral Vascular Disease and Neurodegenerative Disease, Tianjin, China.
Shuai LiuKey Laboratory of Cerebral Vascular Disease and Neurodegenerative Disease, Tianjin, China.
Shuling LiuKey Laboratory of Cerebral Vascular Disease and Neurodegenerative Disease, Tianjin, China.
Jinhuan WangKey Laboratory of Cerebral Vascular Disease and Neurodegenerative Disease, Tianjin, China ; Department of Neurology, Tianjin Huanhu Hospital, Tianjin, China.
Tianjin Huanhu Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAlzheimer's disease (AD) is the leading cause of dementia worldwide and is associated with individual, familial and social burdens. Catechol-O-methyltransferase (COMT) may have a prominent role in AD pathophysiology by affecting the metabolism of catecholamine neurotransmitters and estrogen. Although the COMT rs4680 gene polymorphism has been investigated as a susceptibility factor for AD, the results are inconsistent. The aim of this study was to examine the influence of the COMT rs4680 gene polymorphism as a risk factor for AD in the Han Chinese population and its synergistic effect with the apolipoprotein E (APOE)gene.

methodsA total of 137 AD patients and 194 healthy controls were analyzed. Clinical criteria and neuropsychological tests were used to establish diagnostic groups. All subjects were analyzed for the COMTrs4680 polymorphism and APOEgenotype.

resultsNo significant differences were observed between AD and control subjects regarding the COMT genotype frequencies of Val/Val, Val/Met and Met/Met, but Met alleles were higher in AD than in control subjects (35.4 and 28.1%, p = 0.045). A minor synergistic effect between the genotypes GG and APOEε4 was observed in AD patients (OR: 5.707, 95% CI: 2.505-13.002, p < 0.001). This synergistic effect was greater in women, who showed higher OR of AD (16.007, 95% CI: 4.606-56.118, p < 0.001) versus the AD group with APOE ε4 (11.972, 95% CI: 5.534-25.902, p < 0.001). Furthermore, the COMT Met allele was an independent risk factor for AD without APOE ε4 allele carriers (OR: 1.806, 95% CI: 1.160-2.810, p = 0.009), especially in men (OR: 4.904, 95% CI: 2.381-10.099, p < 0.001).

conclusionThe COMT(Val158Met) polymorphism is not an independent risk factor for AD but shows a synergistic effect between the genotypes GG and APOEε4 that proves greater in women with AD. The COMT Met allele represents a risk factor in AD without APOE ε4 allele carriers, which is notable in men with AD.

Indexed as

Alzheimer's diseaseApolipoprotein ECatechol-O-methyltransferasePolymorphism

Identifiers

PMID24575113
PMCPMC3934601
OpenAlexW1980584171

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.