ArticleFrontiers in neuroanatomy2014
Delineation of motoneuron subgroups supplying individual eye muscles in the human oculomotor nucleus.
Article in Frontiers in neuroanatomy, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 36 citations in OpenAlex.
- Investigations into the anatomical location, physiological function, clinical implications, and significance of the nucleus of Perlia.Acta neurologica Belgica · 2024Pooled it
- A Systematic Review of Direct Outputs from the Cerebellum to the Brainstem and Diencephalon in Mammals.Cerebellum (London, England) · 2024Pooled it
- Propofol Promotes Anesthesia Through the Activation of Centrally-Projecting Edinger-Westphal Nucleus Urocortin 1-Positive Neurons.Neuroscience bulletin · 2025Article
- Macaque monkey trigeminal blink reflex circuits targeting levator palpebrae superioris motoneurons.The Journal of comparative neurology · 2021Article
- Histochemical Characterization of the Vestibular Y-Group in Monkey.Cerebellum (London, England) · 2021Article
- Superior colliculus projections to target populations in the supraoculomotor area of the macaque monkey.Visual neuroscience · 2021Article
- Mouse Extraocular Muscles and the Musculotopic Organization of Their Innervation.Anatomical record (Hoboken, N.J. : 2007) · 2019Article
- Identification of Functional Cell Groups in the Abducens Nucleus of Monkey and Human by Perineuronal Nets and Choline Acetyltransferase Immunolabeling.Frontiers in neuroanatomy · 2018Article
- Identification of secondary vestibulo-ocular neurons in human based on their histochemical characteristics found in monkey.Journal of neurology · 2017Article
- Oculomotor and Vestibular Findings in Gaucher Disease Type 3 and Their Correlation with Neurological Findings.Frontiers in neurology · 2017Article
- Vestibular function in patients with Niemann-Pick type C disease.Journal of neurology · 2016Article
- Functional morphometry demonstrates extraocular muscle compartmental contraction during vertical gaze changes.Journal of neurophysiology · 2016Article
- Article
- Calretinin as a Marker for Premotor Neurons Involved in Upgaze in Human Brainstem.Frontiers in neuroanatomy · 2015Article
- Transmitter inputs to different motoneuron subgroups in the oculomotor and trochlear nucleus in monkey.Frontiers in neuroanatomy · 2015Article
- Modulation of the input-output function by GABAA receptor-mediated currents in rat oculomotor nucleus motoneurons.The Journal of physiology · 2014Article
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5 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
The oculomotor nucleus (nIII) contains the motoneurons of medial, inferior, and superior recti (MR, IR, and SR), inferior oblique (IO), and levator palpebrae (LP) muscles. The delineation of motoneuron subgroups for each muscle is well-known in monkey, but not in human. We studied the transmitter inputs to human nIII and the trochlear nucleus (nIV), which innervates the superior oblique muscle (SO), to outline individual motoneuron subgroups. Parallel series of sections from human brainstems were immunostained for different markers: choline acetyltransferase combined with glutamate decarboxylase (GAD), calretinin (CR) or glycine receptor. The cytoarchitecture was visualized with cresyl violet, Gallyas staining and expression of non-phosphorylated neurofilaments. Apart from nIV, seven subgroups were delineated in nIII: the central caudal nucleus (CCN), a dorsolateral (DL), dorsomedial (DM), central (CEN), and ventral (VEN) group, the nucleus of Perlia (NP) and the non-preganglionic centrally projecting Edinger-Westphal nucleus (EWcp). DL, VEN, NP, and EWcp were characterized by a strong supply of GAD-positive terminals, in contrast to DM, CEN, and nIV. CR-positive terminals and fibers were confined to CCN, CEN, and NP. Based on location and histochemistry of the motoneuron subgroups in monkey, CEN is considered as the SR and IO motoneurons, DL and VEN as the B- and A-group of MR motoneurons, respectively, and DM as IR motoneurons. A good correlation between monkey and man is seen for the CR input, which labels only motoneurons of eye muscles participating in upgaze (SR, IO, and LP). The CCN contained LP motoneurons, and nIV those of SO. This study provides a map of the individual subgroups of motoneurons in human nIII for the first time, and suggests that NP may contain upgaze motoneurons. Surprisingly, a strong GABAergic input to human MR motoneurons was discovered, which is not seen in monkey and may indicate a functional oculomotor specialization.
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