ArticleFrontiers in cellular neuroscience2014
Optogenetic activation of nigral inhibitory inputs to motor thalamus in the mouse reveals classic inhibition with little potential for rebound activation.
Article in Frontiers in cellular neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Characterizing optogenetically mediated rebound effects in anaesthetized mouse primary visual cortex.The Journal of physiology · 2025Article
- Article
- New Targets and New Technologies in the Treatment of Parkinson's Disease: A Narrative Review.International journal of environmental research and public health · 2022Review
- Optogenetic activation of the inhibitory nigro-collicular circuit evokes contralateral orienting movements in mice.Cell reports · 2022Article
- Post-Inhibitory Rebound Firing of Dorsal Root Ganglia Neurons.Journal of pain research · 2022Article
- Input Zone-Selective Dysrhythmia in Motor Thalamus after Dopamine Depletion.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Article
- Revisiting the "Paradox of Stereotaxic Surgery": Insights Into Basal Ganglia-Thalamic Interactions.Frontiers in systems neuroscience · 2021Review
- A Computational Modeling Reveals That Strength of Inhibitory Input, E/I Balance, and Distance of Excitatory Input Modulate Thalamocortical Bursting Properties.Experimental neurobiology · 2019Article
- Neural mechanisms of transient neocortical beta rhythms: Converging evidence from humans, computational modeling, monkeys, and mice.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Spotlight on movement disorders: What optogenetics has to offer.Movement disorders : official journal of the Movement Disorder Society · 2015Article
- Changes in Excitability Properties of Ventromedial Motor Thalamic Neurons in 6-OHDA Lesioned Mice.eNeuroArticle
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2 authors.
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Abstract
The inhibitory output from the internal pallidum and substantia nigra to the thalamus forms an important link in the transmission of basal ganglia processing to cortex. Two hypotheses consider either inhibition of thalamic activity or thalamic excitation via post-inhibitory rebound burst firing as the functional mode of this link. We used optogenetics to characterize the synaptic properties of nigral input to motor thalamus in adult mouse brain slices, and to determine in what conditions the nigral inhibition of motor thalamus is transmitted via inhibition or rebound firing. Our results are more consistent with graded inhibition of spiking for conditions expected in normal awake animals, because inhibitory potentials from nigral input were generally not sufficient to elicit rebound spikes when the thalamic neurons were actively firing. However, with bursty or fast trains of nigral input low-threshold rebound spike bursts could be triggered for low levels of excitation. This may form the basis of pathological burst generation and transmission in parkinsonian conditions.
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