ReviewWorld journal of gastroenterology2014
Inflammatory bowel disease: an increased risk factor for neurologic complications.
Review in World journal of gastroenterology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 2 syntheses or guidelines pooled it, 97 citations in OpenAlex.
- Resting-state functional MRI activity and connectivity in inflammatory bowel disease: a systematic review.Neuroradiology · 2025Pooled it
- Mendelian randomization study shows a causal effect of asthma on epilepsy risk.Frontiers in immunology · 2023Pooled it
- Cerebral Crohn's Disease-Not Your Typical Brain-Gut Connection.Digestive diseases and sciences · 2025Article
- Microbiota-gut-brain Axis: Novel Potential Pathways for Developing Antiepileptogenic Drugs.Current neuropharmacology · 2025Review
- Neurological Side Effects of TNF-α Inhibitors Revisited: A Review of Case Reports.Medicina (Kaunas, Lithuania) · 2024Review
- Wide-spread brain alterations early after the onset of Crohn's disease in children in remission-a pilot study.Frontiers in neuroscience · 2024Article
- Bickerstaff's brainstem encephalitis: a rare case of neurologic complication in Ulcerative Colitis.BMC neurology · 2023Article
- The Impact of Microbiota on the Gut-Brain Axis: Examining the Complex Interplay and Implications.Journal of clinical medicine · 2023Review
- Cachexia, chorea, and pain in chronic nonbacterial osteitis and inflammatory bowel disease: a case report.Journal of medical case reports · 2023Article
- Oculomotor nerve palsy as an extraintestinal manifestation of Crohn's disease.BMJ case reports · 2023Article
- Disseminated strongyloidiasis in a patient with rheumatoid arthritis: A case report.World journal of clinical cases · 2022Article
- Sensorineural hearing loss and ulcerative colitis in remission.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2022Observational
- Acute transverse myelitis in an adult-patient with underlying ulcerative colitis: a case report.BMC gastroenterology · 2022Article
- Importance of crosstalk between the microbiota and the neuroimmune system for tissue homeostasis.Clinical & translational immunology · 2022Review
- Inflammatory Bowel Disease and Patients With Mental Disorders: What Do We Know?Journal of clinical medicine research · 2021Review
- Brain functional changes in patients with Crohn's disease: A resting-state fMRI study.Brain and behavior · 2021Article
- Acute longitudinal extensive transverse myelitis secondary to asymptomatic SARS-CoV-2 infection.BMJ case reports · 2021Article
- New Horizons for Diagnostic Pitfalls of Cerebral Venous Thrombosis: Clinical Utility of a Newly Developed Cerebral Venous Thrombosis Diagnostic Score: A Case Report and Literature Review.The American journal of case reports · 2021Review
- Cerebrospinal Fluid and Plasma Lipopolysaccharide Levels in Human Immunodeficiency Virus Type 1 Infection and Associations With Inflammation, Blood-Brain Barrier Permeability, and Neuronal Injury.The Journal of infectious diseases · 2021Article
- Mapping the relationships between inflammatory bowel disease and comorbid diagnoses to identify disease associations.European journal of gastroenterology & hepatology · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Only a very few systematic studies have investigated the frequency of neurologic disorders in patients with Crohn's disease (CD) and ulcerative colitis (UC), which are the two main types of inflammatory bowel disease (IBD). Results have been inconsistent and variable, owing to differences in case-finding methods and evaluated outcomes in different studies. The most frequent neurologic manifestations reported in CD and UC populations are cerebrovascular disease (with either arterial or venous events), demyelinating central nervous system disease, and peripheral neuropathy (whether axonal or demyelinating); however, the literature describes numerous nervous system disorders as being associated with IBD. The pathogenesis of nervous system tissue involvement in IBD has yet to be elucidated, although it seems to be related to immune mechanisms or prothrombotic states. The recently-introduced tumor necrosis factor (TNF) inhibitors have proven successful in controlling moderate to severe IBD activity. However, severe neurologic disorders associated with TNF inhibitors have been reported, which therefore raises concerns regarding the effect of anti-TNF-α antibodies on the nervous system. Although neurological involvement associated with IBD is rarely reported, gastroenterologists should be aware of the neurologic manifestations of IBD in order to provide early treatment, which is crucial for preventing major neurologic morbidity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.