Evidence map›Paper›PMID 24574704›Full record

ReviewWorld journal of gastroenterology2014

Epigenetics in hepatocellular carcinoma: an update and future therapy perspectives.

Li Ma, Mei-Sze Chua, Ourania Andrisani, Samuel So

Open access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in World journal of gastroenterology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.

0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed
5.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

59 citing papers in PubMed, 115 citations in OpenAlex.

  1. Trial
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  7. Metachronous multifocal carcinoma: A case report.World journal of gastrointestinal oncology · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Li MaLi Ma, Mei-Sze Chua, Samuel So, Asian Liver Center and Department of Surgery, Stanford University School of Medicine, Stanford University, Stanford, CA 94305, United States.
Mei-Sze ChuaLi Ma, Mei-Sze Chua, Samuel So, Asian Liver Center and Department of Surgery, Stanford University School of Medicine, Stanford University, Stanford, CA 94305, United States.
Ourania AndrisaniLi Ma, Mei-Sze Chua, Samuel So, Asian Liver Center and Department of Surgery, Stanford University School of Medicine, Stanford University, Stanford, CA 94305, United States.
Samuel SoLi Ma, Mei-Sze Chua, Samuel So, Asian Liver Center and Department of Surgery, Stanford University School of Medicine, Stanford University, Stanford, CA 94305, United States.
Stanford University · US

Funding

Role of CREB/ATF Proteins in Hepatocyte Growth ControlR01DK044533 · NIDDK · PURDUE UNIVERSITY WEST LAFAYETTE · PI ANDRISANI, OURANIA M. · 1999 to 2021
$5.1M
NIDDK NIH HHS R01 DK044533
6 · The paper itself

Abstract

Hepatocellular carcinoma (HCC), the predominant form of adult liver malignancies, is a global health concern. Its dismal prognosis has prompted recent significant advances in the understanding of its etiology and pathogenesis. The deregulation of epigenetic mechanisms, which maintain heritable gene expression changes and chromatin organization, is implicated in the development of multiple cancers, including HCC. This review summarizes the current knowledge of epigenetic mechanisms in the pathogenesis of HCC, with an emphasis on HCC mediated by chronic hepatitis B virus infection. This review also discusses the encouraging outcomes and lessons learnt from epigenetic therapies for hematological and other solid cancers, and highlights the future potential of similar therapies in the treatment of HCC.

Indexed as

Epigenesis, GeneticAnimalsAntineoplastic AgentsCarcinoma, HepatocellularChromatin Assembly and DisassemblyDNA MethylationGene Expression Regulation, NeoplasticGenetic Predisposition to DiseaseGenetic TherapyHepatitis B, ChronicHistonesHumansLiver NeoplasmsMicroRNAsNeoplastic Stem CellsPhenotypeAntineoplastic AgentsHistonesMicroRNAsRNA, Long NoncodingDNA methylationEpigeneticsHepatocellular carcinomaHistone modificationlncRNAmiRNA

Identifiers

PMID24574704
PMCPMC3923010
OpenAlexW2082095180

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.