ArticleJournal of oral and maxillofacial pathology : JOMFP2013
VEGF and CD 34: A correlation between tumor angiogenesis and microvessel density-an immunohistochemical study.
Article in Journal of oral and maxillofacial pathology : JOMFP, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 45 citations in OpenAlex.
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- Promotion of angiogenesis in cerebral infarction by Tongqiao Huoxue Decoction through activation of glycolysis.Metabolic brain disease · 2025Article
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- The Three-Dimensional In Vitro Cell Culture Models in the Study of Oral Cancer Immune Microenvironment.Cancers · 2023Review
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- VEGF Expression, Cellular Infiltration, and Intratumoral Collagen Levels after Electroporation-Based Treatment of Dogs with Cutaneous Squamous Cell Carcinoma.Life (Basel, Switzerland) · 2021Article
- Ocular surface angiography: from neovessels to neoplasia.BMJ open ophthalmology · 2021Review
- Preliminary Post-Mortem COVID-19 Evidence of Endothelial Injury and Factor VIII Hyperexpression.Diagnostics (Basel, Switzerland) · 2020Article
- Marine fish peptides (collagen peptides) compound intake promotes wound healing in rats after cesarean section.Food & nutrition research · 2020Article
- Cathepsin L-induced galectin-1 may act as a proangiogenic factor in the metastasis of high-grade serous carcinoma.Journal of translational medicine · 2019Article
- Salivary levels and immunohistochemical expression of selected angiogenic factors in benign and malignant parotid gland tumours.Clinical oral investigations · 2019Article
- Allogeneic transplantation of programmable cells of monocytic origin (PCMO) improves angiogenesis and tissue recovery in critical limb ischemia (CLI): a translational approach.Stem cell research & therapy · 2018Article
- Cytotoxic Effect of Thiabendazole on Hn5 Head and Neck Squamous Cell Carcinoma Cell Line.Journal of dentistry (Shiraz, Iran) · 2017Article
- The Potential Roles of MELF-Pattern, Microvessel Density, and VEGF Expression in Survival of Patients with Endometrioid Endometrial Carcinoma: A Morphometrical and Immunohistochemical Analysis of 100 Cases.Journal of pathology and translational medicine · 2017Article
- CD24 promoted cancer cell angiogenesis via Hsp90-mediated STAT3/VEGF signaling pathway in colorectal cancer.Oncotarget · 2016Article
- Effects of receptor for advanced glycation endproducts on microvessel formation in endometrial cancer.BMC cancer · 2016Article
- Vascular endothelial growth factor expression and vascular density in oral squamous cell carcinoma (OSCC): A study on clinical and histopathologic significance.Medical journal of the Islamic Republic of Iran · 2016Article
- Different approaches for interpretation and reporting of immunohistochemistry analysis results in the bone tissue - a review.Diagnostic pathology · 2014Review
- Value of micro-CT for monitoring spinal microvascular changes after chronic spinal cord compression.International journal of molecular sciences · 2014Article
- CD34 Angiogenesis Marker in Oral Squamous Cell Carcinoma: An Immunohistochemical Study.Contemporary clinical dentistryArticle
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAngiogenesis is the formation of new vessels from preexisting ones which takes place by capillary sprouting. It is seen in healing, at sites of injury and collateral circulation in ischemia. It is also seen in tumors, as once the original blood supply of a tumor is exhausted it cannot grow without further blood supply. Also as the angiogenic capacity of a tumor increases, its microvasculature, that is, microvessel density (MVD) also increases. Based on this literary evidence we carried out an immunohistochemical (IHC) study to observe the relationship between the expression of vascular endothelial growth factor (VEGF) [angiogenesis] and CD 34 [MVD] in oral squamous cell carcinoma (OSCC).
aimTo evaluate the correlation between expression of VEGF and CD 34, the role of MVD in progression of OSCC and to compare the degree of angiogenesis in different grades of OSCC. SETTINGS AND
designIn this study we observed the relation between angiogenesis and MVD and the overall effect of this on oral cancer. MATERIALS AND
methodsThirty-three cases of OSCC were stained with hematoxylin and eosin, (H and E) to confirm the diagnosis and immunohistochemically using VEGF and CD 34 antibody. The slides were evaluated for positivity and intensity of staining. STATISTICAL ANALYSIS: The result was subjected to statistical analysis using analysis of variance (ANOVA) test and Fisher's exact test.
resultsVEGF positivity as well as MVD was found to be independent of the grade of the tumor. Tumor MVD was found to be independent of expression of VEGF.
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