ReviewThe Journal of experimental biology2014
Established and potential physiological roles of bicarbonate-sensing soluble adenylyl cyclase (sAC) in aquatic animals.
Review in The Journal of experimental biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 52 citations in OpenAlex.
- Soluble adenylyl cyclase in nonmammalian sperm is directly controlled by pH, not by HCOProceedings of the National Academy of Sciences of the United States of America · 2026Article
- Comparative physiology reveals heat stress disrupts acid-base homeostasis independent of symbiotic state in the model cnidarian Exaiptasia diaphana.The Journal of experimental biology · 2024Article
- Characterization of a sperm motility signalling pathway in a gonochoric coral suggests conservation across cnidarian sexual systems.Proceedings. Biological sciences · 2023Article
- The silent loss of cell physiology hampers marine biosciences.PLoS biology · 2022Article
- Molecular and biochemical characterization of the bicarbonate-sensing soluble adenylyl cyclase from a bony fish, the rainbow troutInterface focus · 2021Article
- Characteristics and Cryopreservation of Semen of Sex-Reversed Females of Salmonid Fish.International journal of molecular sciences · 2021Review
- Pharmacological modulation of the COPharmacology & therapeutics · 2018Review
- Analysis ofFrontiers in physiology · 2018Article
- Subcellular localization and characterization of estrogenic pathway regulators and mediators in Atlantic salmon spermatozoal cells.Histochemistry and cell biology · 2018Article
- Identification of a molecular pH sensor in coral.Proceedings. Biological sciences · 2017Article
- Bicarbonate-sensing soluble adenylyl cyclase is present in the cell cytoplasm and nucleus of multiple shark tissues.Physiological reports · 2017Article
- Introducing a novel mechanism to control heart rate in the ancestral Pacific hagfish.The Journal of experimental biology · 2016Article
- Gymnocypris przewalskii decreases cytosolic carbonic anhydrase expression to compensate for respiratory alkalosis and osmoregulation in the saline-alkaline lake Qinghai.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2016Article
- Soluble adenylyl cyclase in health and disease.Biochimica et biophysica acta · 2014Review
- Soluble adenylyl cyclase of sea urchin spermatozoa.Biochimica et biophysica acta · 2014Review
- Feeding induces translocation of vacuolar proton ATPase and pendrin to the membrane of leopard shark (Triakis semifasciata) mitochondrion-rich gill cells.Comparative biochemistry and physiology. Part A, Molecular & integrative physiology · 2014Article
- Temperature tolerance of different larval stages of the spider crab Hyas araneus exposed to elevated seawater PCO2.Frontiers in zoology · 2014Article
- Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Soluble adenylyl cyclase (sAC) is a recently recognized source of the signaling molecule cyclic AMP (cAMP) that is genetically and biochemically distinct from the classic G-protein-regulated transmembrane adenylyl cyclases (tmACs). Mammalian sAC is distributed throughout the cytoplasm and it may be present in the nucleus and inside mitochondria. sAC activity is directly stimulated by HCO3(-), and sAC has been confirmed to be a HCO3(-) sensor in a variety of mammalian cell types. In addition, sAC can functionally associate with carbonic anhydrases to act as a de facto sensor of pH and CO2. The two catalytic domains of sAC are related to HCO3(-)-regulated adenylyl cyclases from cyanobacteria, suggesting the cAMP pathway is an evolutionarily conserved mechanism for sensing CO2 levels and/or acid/base conditions. Reports of sAC in aquatic animals are still limited but are rapidly accumulating. In shark gills, sAC senses blood alkalosis and triggers compensatory H(+) absorption. In the intestine of bony fishes, sAC modulates NaCl and water absorption. And in sea urchin sperm, sAC may participate in the initiation of flagellar movement and in the acrosome reaction. Bioinformatics and RT-PCR results reveal that sAC orthologs are present in most animal phyla. This review summarizes the current knowledge on the physiological roles of sAC in aquatic animals and suggests additional functions in which sAC may be involved.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.