ReviewSchizophrenia bulletin2014
Generalized and specific neurocognitive deficits in psychotic disorders: utility for evaluating pharmacological treatment effects and as intermediate phenotypes for gene discovery.
Review in Schizophrenia bulletin, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.
- Integrating Clinical Neuropsychology and Psychotic Spectrum Disorders: A Systematic Analysis of Cognitive Dynamics, Interventions, and Underlying Mechanisms.Medicina (Kaunas, Lithuania) · 2024Pooled it
- Relationship of Cognition to Clinical Response in First-Episode Schizophrenia Spectrum Disorders.Schizophrenia bulletin · 2015Trial
- Relationship between cognitive functions and serum neurotrophic factor levels in long-term hospitalized male patients with schizophrenia.BMC psychiatry · 2025Article
- Evaluating causal psychological models: A study of language theories of autism using a large sample.Frontiers in psychology · 2023Article
- Identifying transdiagnostic biological subtypes across schizophrenia, bipolar disorder, and major depressive disorder based on lipidomics profiles.Frontiers in cell and developmental biology · 2022Article
- Transcranial direct current stimulation of the occipital lobes with adjunct lithium attenuates the progression of cognitive impairment in patients with first episode schizophrenia.Frontiers in psychiatry · 2022Article
- Associations of cognitive impairment in patients with schizophrenia with genetic features and with schizophrenia-related structural and functional brain changes.Frontiers in genetics · 2022Article
- Violence, neurocognitive function and clinical correlates in patients with schizophrenia.Frontiers in psychiatry · 2022Article
- Reduced white matter microstructure in bipolar disorder with and without psychosis.Bipolar disorders · 2021Article
- Genome-wide association study accounting for anticholinergic burden to examine cognitive dysfunction in psychotic disorders.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Article
- Transdiagnostic comparison of visual working memory capacity in bipolar disorder and schizophrenia.International journal of bipolar disorders · 2021Article
- Generalized neurocognitive impairment in individuals at ultra-high risk for psychosis: The possible key role of slowed processing speed.Brain and behavior · 2021Article
- Catechol-O-methyltransferase genotype differentially contributes to the flexibility and stability of cognitive sets in patients with psychotic disorders and their first-degree relatives.Schizophrenia research · 2020Article
- Distinguishing patterns of impairment on inhibitory control and general cognitive ability among bipolar with and without psychosis, schizophrenia, and schizoaffective disorder.Schizophrenia research · 2020Article
- Multivariate Relationships Between Cognition and Brain Anatomy Across the Psychosis Spectrum.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2018Article
- Deficits in visual working-memory capacity and general cognition in African Americans with psychosis.Schizophrenia research · 2018Article
- Deviation from expected cognitive ability across psychotic disorders.Schizophrenia research · 2018Article
- Assessing the Relationship between Performance on the University of California Performance Skills Assessment (UPSA) and Outcomes in Schizophrenia: A Systematic Review and Evidence Synthesis.Schizophrenia research and treatment · 2018Review
- Explicit and implicit reinforcement learning across the psychosis spectrum.Journal of abnormal psychology · 2017Article
- Transdiagnostic Associations Between Functional Brain Network Integrity and Cognition.JAMA psychiatry · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
A growing body of research suggests that schizophrenia and bipolar disorder share overlapping clinical, neurobiological, and genetic features, raising important questions about the boundaries and distinctiveness of these 2 major psychiatric disorders. A generalized cognitive impairment has long been understood to be a core feature of schizophrenia. More recently, it has become apparent that cognitive impairment also occurs in bipolar disorder, particularly in those patients with a history of psychotic symptoms. Whether a generalized deficit exists across a spectrum of psychotic disorders is less clearly established. Additionally, in the context of a broad impairment, it remains a significant challenge to identify deficits in specific cognitive processes that may have distinct neurochemical or regional brain substrates and linkages to particular risk-associated genetic factors. In this article, we review the findings from neuropsychological studies across a spectrum that includes schizophrenia, schizoaffective and bipolar disorders, and conclude the available evidence strongly supports that a generalized deficit is present across psychotic disorders that differs in severity more so than form. We then consider the implications of generalized and specific deficits in psychosis for 2 areas of research--the evaluation of pharmacological treatments targeting cognitive deficits, and the investigation of cognitive intermediate phenotypes in family genetic studies. Examples from the literature that touch on the relevance of the generalized deficit in these contexts are provided, as well as consideration for the continued need to identify specific impairments that are separable from the generalized deficit in order to advance drug and gene discovery.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.