ArticleArthritis & rheumatology (Hoboken, N.J.)2014
Determinants of mortality among postmenopausal women in the women's health initiative who report rheumatoid arthritis.
Article in Arthritis & rheumatology (Hoboken, N.J.), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 36 citations in OpenAlex.
- Associations of food security and food assistance with cardiovascular morbidity and mortality among postmenopausal women from the women's health initiative.Journal of epidemiology and community health · 2026Article
- Subclinical atherosclerosis in rheumatoid arthritis: a case cohort analysis from ELSA-Brasil.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas · 2026Article
- The temporal mortality trend in seropositive and seronegative rheumatoid arthritis: a Danish population-based cohort study.EULAR rheumatology open · 2025Article
- Article
- Tumor-Associated and Systemic Autoimmunity in Pre-Clinical Breast Cancer among Post-Menopausal Women.Biomolecules · 2023Article
- Different Clinical Relevance of Anti-Citrullinated Protein Antibodies in RA Patients.Doklady. Biochemistry and biophysics · 2023Article
- Association between psoriasis and thyroid function: results from the Brazilian Longitudinal Study of Adults Health (ELSA-Brasil).Archives of endocrinology and metabolism · 2023Article
- Chronic inflammatory diseases, subclinical atherosclerosis, and cardiovascular diseases: Design, objectives, and baseline characteristics of a prospective case-cohort study ‒ ELSA-Brasil.Clinics (Sao Paulo, Brazil) · 2022Article
- Article
- Sex differences in the association between antinuclear antibody positivity with diabetes and multimorbidity in older adults: Results from the Baltimore Longitudinal Study of Aging.Experimental gerontology · 2020Article
- ACPAs promote IL-1β production in rheumatoid arthritis by activating the NLRP3 inflammasome.Cellular & molecular immunology · 2020Article
- Lifetime Pesticide Use and Antinuclear Antibodies in Male Farmers From the Agricultural Health Study.Frontiers in immunology · 2019Article
- Smoking Behavior Changes in the Early Rheumatoid Arthritis Period and Risk of Mortality During Thirty-Six Years of Prospective Followup.Arthritis care & research · 2018Article
- Human Leukocyte Antigen Shared Epitope and Inflammation, Cardiovascular Disease, Cancer, and Mortality Among Postmenopausal Women in the Women's Health Initiative Rheumatoid Arthritis Study.American journal of epidemiology · 2017Article
- Menopause and Rheumatic Disease.Rheumatic diseases clinics of North America · 2017Review
- Anticitrullinated protein antibodies: origin and role in the pathogenesis of rheumatoid arthritis.Current opinion in rheumatology · 2017Review
- Anti-carbamylated protein autoantibodies associated with mortality in Spanish rheumatoid arthritis patients.PloS one · 2017Article
- Rheumatoid Arthritis and Mortality Among Women During 36 Years of Prospective Follow-Up: Results From the Nurses' Health Study.Arthritis care & research · 2016Article
- Rheumatoid Arthritis, Anti-Cyclic Citrullinated Peptide Positivity, and Cardiovascular Disease Risk in the Women's Health Initiative.Arthritis & rheumatology (Hoboken, N.J.) · 2015Observational
- Rheumatoid arthritis in the Women's Health Initiative: methods and baseline evaluation.American journal of epidemiology · 2014Article
Corrections and comments
- Erratum issued
Authors and funding
12 authors at 7 institutions in 1 country.
Funding
Abstract
objectiveRheumatoid arthritis (RA) patients have an increased risk of cardiovascular disease (CVD) and mortality. We measured anti-cyclic citrullinated peptide (anti-CCP) antibody levels and determined use of disease-modifying antirheumatic drugs (DMARDs) among women in the Women's Health Initiative (WHI). Using these data, we undertook this study to assess total mortality over 10 years of followup among white, black, or Hispanic women with self-reported RA in the WHI.
methodsUsing stored baseline serum, we measured anti-CCP, rheumatoid factor (RF), and antinuclear antibodies (ANAs) in 9,988 women who reported having RA. Based on a previous chart review study, probable RA was defined as either self-reported RA and anti-CCP positivity, or anti-CCP negativity and DMARD use. Cox proportional hazards regression was used to model the relationship of self-reported RA, DMARD exposure, and anti-CCP positivity to total mortality, using followup data through April 2009.
resultsAt baseline, the mean age was 62.8 years; 24.5% of subjects were black and 10% were Hispanic. Prevalence of anti-CCP positivity was 8.1% (n = 812), and 217 women were anti-CCP negative but had reported use of DMARDs; therefore, 1,029 women (of 9,988) were classified as having probable RA, and 8,958 were classified as unlikely to have RA (with data on DMARD use missing for 1 subject). Age-adjusted mortality rates were ∼2-fold higher for anti-CCP-positive women, with 20.2 deaths per 1,000 person-years, as compared to 11.4 deaths per 1,000 person-years among anti-CCP-negative women with self-reported RA who never used DMARDs. Among women who did not report any arthritis at baseline, we found 8.3 deaths per 1,000 person-years. The increased risk among anti-CCP-positive women with RA was not explained by age, RF positivity, ANA positivity, or DMARD use.
conclusionAnti-CCP-positive RA was associated with substantial excess mortality among postmenopausal women in the WHI. This result was not explained by the risk factors we measured.
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