Evidence map›Paper›PMID 24574081›Full record

ArticleObesity (Silver Spring, Md.)2014

Hyperphagia: current concepts and future directions proceedings of the 2nd international conference on hyperphagia.

Steven B Heymsfield, Nicole M Avena, Leslie Baier, Phillip Brantley, George A Bray, Lisa C Burnett, Merlin G Butler, Daniel J Driscoll, Dieter Egli, Joel Elmquist and 19 more

Open access · bronzeAbstract readConference Proceedings
In one paragraph

Article in Obesity (Silver Spring, Md.), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
70citing papers in PubMed, 3 pooled it
4.2field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

70 citing papers in PubMed, 3 syntheses or guidelines pooled it, 128 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Trial
  6. Hunger pain and its reduction; qualitative insight from people with schizophrenia on semaglutide.International journal of qualitative studies on health and well-being · 2026
    Article
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  9. Review
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  17. Hyperphagia in Bardet-Biedl syndrome: Pathophysiology, burden, and management.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2025
    Review
  18. Review
  19. Article
  20. Article

10 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

29 authors at 20 institutions in 4 countries.

Steven B HeymsfieldPennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana, USA.
Nicole M Avena
Leslie Baier
Phillip Brantley
George A Bray
Lisa C Burnett
Merlin G Butler
Daniel J Driscoll
Dieter Egli
Joel Elmquist
Janice L Forster
Anthony P Goldstone
Linda M Gourash
Frank L Greenway
Joan C Han
James G Kane
Rudolph L Leibel
Ruth J F Loos
Ann O Scheimann
Christian L Roth
Randy J Seeley
Val Sheffield
Maïthé Tauber
Christian Vaisse
Liheng Wang
Robert A Waterland
Rachel Wevrick
Jack A Yanovski
Andrew R Zinn
Columbia University · USPennington Biomedical Research Center · USEunice Kennedy Shriver National Institute of Child Health and Human Development · USChildren's Nutrition Research Center at Baylor College of Medicine · USFlorida College · USIcahn School of Medicine at Mount Sinai · USJohns Hopkins University · USLouisiana State University System · USNational Institute of Diabetes and Digestive and Kidney Diseases · USNIHR Imperial Biomedical Research Centre · GBPrader Willi Syndrome Association · USSouthwestern Medical CenterThe University of Texas Southwestern Medical Center · USUniversité Toulouse III - Paul Sabatier · FRUniversity Medical Center · USUniversity of Alberta · CAUniversity of California, San Francisco · USUniversity of Cincinnati · USUniversity of Florida · USUniversity of Iowa · US

Funding

WHITE MATTER AND COGNITION IN PARKINSON'S DISEASEM01RR000082 · NCRR · UNIVERSITY OF FLORIDA · PI FOOTE, KELLY D · 1985 to 2009
$29.7M
Physiology, Psychology, and Genetics of ObesityZIAHD000641 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI YANOVSKI, JACK A. · 2009 to 2025
$24.8M
Research Design and Analysis Core (RDAC)P30HD002528 · NICHD · UNIVERSITY OF KANSAS LAWRENCE · PI FOWLER, STEPHEN CLETIUS · 1985 to 2015
$22.1M
Novel Mechanisms Regulating the Adipocyte-Brain-Hepatocyte AxisP01DK088761 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI SCHERER, PHILIPP E · 2010 to 2019
$17.4M
Structural Analysis Of Candidate Genes For Type 2 Diabetes and ObesityZIADK069071 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI BAIER, LESLIE J · 2009 to 2025
$15.4M
UF CLINICAL AND TRANSLATIONAL SCIENCE AWARDUL1RR029890 · NCRR · UNIVERSITY OF FLORIDA · PI NELSON, DAVID R · 2009 to 2011
$14.4M
Training and Career Development ComponentU54HD061222 · NICHD · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI PERCY, ALAN KENNETH · 2009 to 2019
$12.4M
The Melanocortin-4 Receptor in Human ObesityR01DK060540 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHRISTIAN VAISSE · 2002 to 2026
$7.5M
Treatment of a Complex Retinal Degenerative SyndromeR01EY011298 · NEI · UNIVERSITY OF IOWA · PI SHEFFIELD, VAL C. · 1996 to 2017
$7.3M
RARE DISEASE CRC FOR NEW THERAPIES AND NEW DIAGNOSTICSU54RR019478 · NCRR · BAYLOR COLLEGE OF MEDICINE · PI BEAUDET, ARTHUR L. · 2003 to 2008
$7.3M
Interdisciplinary approach to retinal disease gene identificationR01EY017168 · NEI · UNIVERSITY OF IOWA · PI SHEFFIELD, VAL C. · 2007 to 2017
$5.9M
Central Mechanisms Regulating Energy Homeostasis, Project 2 of 10RL1DK081185 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI ELMQUIST, JOEL K. · 2007 to 2011
$3.8M
Intramural NIH HHS Z01 DK069098Intramural NIH HHS Z99 DK999999Intramural NIH HHS Z99 HD999999Intramural NIH HHS ZIA DK069071Intramural NIH HHS ZIA HD000641NCRR NIH HHS M01 RR000082NCRR NIH HHS U54 RR019478NCRR NIH HHS UL1 RR029890NEI NIH HHS R01 EY011298NEI NIH HHS R01 EY017168NICHD NIH HHS K24 HD001361NICHD NIH HHS P30 HD002528NICHD NIH HHS U54 HD061222NIDDK NIH HHS K23 DK081203NIDDK NIH HHS P01 DK088761NIDDK NIH HHS R01 DK053301NIDDK NIH HHS R01 DK060540NIDDK NIH HHS R01 DK068152NIDDK NIH HHS R01 DK079986NIDDK NIH HHS R01 DK090382NIDDK NIH HHS RL1 DK081185
6 · The paper itself

Abstract

objectiveHyperphagia is a central feature of inherited disorders (e.g., Prader-Willi Syndrome) in which obesity is a primary phenotypic component. Hyperphagia may also contribute to obesity as observed in the general population, thus raising the potential importance of common underlying mechanisms and treatments. Substantial gaps in understanding the molecular basis of inherited hyperphagia syndromes are present as are a lack of mechanistic of mechanistic targets that can serve as a basis for pharmacologic and behavioral treatments. DESIGN AND

methodsInternational conference with 28 experts, including scientists and caregivers, providing presentations, panel discussions, and debates.

resultsThe reviewed collective research and clinical experience provides a critical body of new and novel information on hyperphagia at levels ranging from molecular to population. Gaps in understanding and tools needed for additional research were identified.

conclusionsThis report documents the full scope of important topics reviewed at a comprehensive international meeting devoted to the topic of hyperphagia and identifies key areas for future funding and research.

Indexed as

ResearchBasic Helix-Loop-Helix ProteinsBehavior, AddictiveCraniopharyngiomaEatingFeeding BehaviorFemaleHumansHyperphagiaMaleModels, AnimalObesityOdds RatioPhenotypePrader-Willi SyndromeRepressor ProteinsBasic Helix-Loop-Helix ProteinsRepressor ProteinsSIM1 protein, human

Identifiers

PMID24574081
PMCPMC4159941
OpenAlexW1940156094

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.