ReviewClinical medicine & research2014
The role of aspirin in the prevention of cardiovascular disease.
Review in Clinical medicine & research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05845489 (Efficacy and Safety of Clopidogrel for Primary Prevention in Patients With Subclinical Coronary Atherosclerosis Identified on Imaging), which is not on this map. Cited by 85 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Efficacy and Safety of Clopidogrel for Primary Prevention in Patients With Subclinical Coronary Atherosclerosis Identified on Imaging
Who cites it
85 citing papers in PubMed, 4 syntheses or guidelines pooled it, 202 citations in OpenAlex.
- Pooled it
- Benefits and Risks Associated With Aspirin Use in Patients With Diabetes for the Primary Prevention of Cardiovascular Events and Mortality: A Meta-Analysis.Frontiers in endocrinology · 2021Pooled it
- Effect of low-dose aspirin on health outcomes: An umbrella review of systematic reviews and meta-analyses.British journal of clinical pharmacology · 2020Pooled it
- Medications and Prescribing Patterns as Factors Associated with Hospitalizations from Long-Term Care Facilities: A Systematic Review.Drugs & aging · 2018Pooled it
- Effect of Aspirin on Cardiovascular Events and Bleeding in the Healthy Elderly.The New England journal of medicine · 2018Trial
- Progress in Synthesis and Pharmacology of Telmisartan.Chemistry & biodiversity · 2026Review
- The History of Coronary Artery Disease.The International journal of angiology : official publication of the International College of Angiology, Inc · 2025Review
- Practical guide to management after an acute pulmonary embolism.BMJ open respiratory research · 2025Review
- Associations of genetic proxies for non-steroidal anti-inflammatory drugs with increased kidney stone risk: a Mendelian randomization study.Inflammopharmacology · 2025Article
- Identification of biomarkers associated with phagocytosis regulatory factors in coronary artery disease using machine learning and network analysis.Mammalian genome : official journal of the International Mammalian Genome Society · 2025Article
- Association between prophylactic aspirin use and hypertension using data from NHANES 2011-2018.Scientific reports · 2024Article
- Continuous aspirin treatment improves cardiovascular events and all-cause mortality in hemodialysis patients with peripheral artery disease.Renal failure · 2024Article
- Pharmacogenomics revolutionizing cardiovascular therapeutics: A narrative review.Health science reports · 2024Article
- Nonadherence to Cardiovascular Drugs Predicts Risk for Non-Arthritic Anterior Ischemic Optic Neuropathy: A Large-Scale National Study.Journal of clinical medicine · 2024Article
- Article
- The Role of the Vascular System in Degenerative Diseases: Mechanisms and Implications.International journal of molecular sciences · 2024Review
- Effect of Low-Dose Aspirin on the Elderly.Cureus · 2024Review
- Aspirin inhibits rotavirus replication and alters rat gut microbial composition.Virology journal · 2023Article
- A Mild Dose of Aspirin Promotes Hippocampal Neurogenesis and Working Memory in Experimental Ageing Mice.Brain sciences · 2023Article
- Prevention of aspirin-mediated secondary toxicity by combined treatment of carotenoids in macrophages.3 Biotech · 2023Article
25 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aspirin therapy is well-accepted as an agent for the secondary prevention of cardiovascular events and current guidelines also define a role for aspirin in primary prevention. In this review, we describe the seminal trials of aspirin use in the context of current guidelines, discuss factors that may influence the effectiveness of aspirin therapy for cardiovascular disease prevention, and briefly examine patterns of use. The body of evidence supports a role for aspirin in both secondary and primary prevention of cardiovascular events in selected population groups, but practice patterns may be suboptimal. As a simple and inexpensive prophylactic measure for cardiovascular disease, aspirin use should be carefully considered in all at-risk adult patients, and further measures, including patient education, are necessary to ensure its proper use.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.