ArticleJournal of molecular evolution2014
From promiscuity to the lipid divide: on the evolution of distinct membranes in Archaea and Bacteria.
Article in Journal of molecular evolution, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 56 citations in OpenAlex.
- Tat-dependent protein translocation and its evolution.FEMS microbiology reviews · 2026Review
- Structural basis and evolutionary pathways of glycerol-1-phosphate transport in marine bacteria.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- A comprehensive database for high-throughput identification of archaeal lipids using high-resolution mass spectrometry.Nature communications · 2025Article
- The role of ester- versus ether-linked phospholipids in the ability of biological membranes to accept protons and support proton diffusion.Biophysical journal · 2025Article
- Relationship troubles at the mitochondrial level and what it might mean for human disease.Open biology · 2025Review
- The Possible Crystallization Process in the Origin of Bacteria, Archaea, Viruses, and Mobile Elements.Biology · 2024Article
- Structure Diversity and Properties of Some Bola-like Natural Products.Marine drugs · 2024Review
- Tetraether archaeal lipids promote long-term survival in extreme conditions.Molecular microbiology · 2024Article
- Cholesterol, Eukaryotic Lipid Domains, and an Evolutionary Perspective of Transmembrane Signaling.Cold Spring Harbor perspectives in biology · 2023Review
- Potential of atmospheric pressure ionization sources for the analysis of free fatty acids in clinical and biological samples by gas chromatography-mass spectrometry.Analytical and bioanalytical chemistry · 2022Article
- The catalytic and structural basis of archaeal glycerophospholipid biosynthesis.Extremophiles : life under extreme conditions · 2022Review
- Total Synthesis of the Alleged Structure of Crenarchaeol Enables Structure Revision*.Angewandte Chemie (International ed. in English) · 2021Article
- The Origin(s) of Cell(s): Pre-Darwinian Evolution from FUCAs to LUCA : To Carl Woese (1928-2012), for his Conceptual Breakthrough of Cellular Evolution.Journal of molecular evolution · 2021Article
- Article
- The archaeal-bacterial lipid divide, could a distinct lateral proton route hold the answer?Biology direct · 2020Article
- Interaction of salt with ether- and ester-linked phospholipid bilayers.Biochimica et biophysica acta. Biomembranes · 2019Article
- Investigating the Origins of Membrane Phospholipid Biosynthesis Genes Using Outgroup-Free Rooting.Genome biology and evolution · 2019Article
- A linear pathway for mevalonate production supports growth of Thermococcus kodakarensis.Extremophiles : life under extreme conditions · 2019Article
- Calditol-linked membrane lipids are required for acid tolerance inProceedings of the National Academy of Sciences of the United States of America · 2018Article
- Glycerol Phosphate Cytidylyltransferase Stereospecificity Is Key to Understanding the Distinct Stereochemical Compositions of Glycerophosphoinositol in Bacteria and Archaea.Applied and environmental microbiology · 2017Article
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1 author at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
The structural and biosynthetic features of archaeal phospholipids provide clues to the membrane lipid composition in the last universal common ancestor (LUCA) membranes. The evident similarity of the phospholipid biosynthetic pathways in Archaea and Bacteria suggests that one set of these biosynthetic enzymes would have worked on a wide range of lipids composed of enantiomeric glycerophosphate backbones linked with a variety of hydrocarbon chains. This notion was supported by the discovery of a wide range reactivity of enzymes belonging to the CDP-alcohol phosphatidyltransferase family. It is hypothesized that lipid promiscuity is generated from the prebiotic surface metabolism on pyrite proposed by Wächtershäuser. The significance of the phosphate groups on the intermediates of phospholipid biosynthesis and the extra anionic groups of a polar head group suggested the likely involvement of surface metabolism. Anionic groups are essential for surface metabolism. Since the early chemical evolution reactions are presumed to be non-specific, every combination of the available lipid component parts would be expected to be formed. The mixed lipid membranes present in LUCA were segregated and this led to the differentiation of Archaea and Bacteria, as described previously. The proper arrangement of membrane lipids was generated by the physicochemical drive arising from the promiscuity of the primordial membrane lipids.
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