ArticleEuropean journal of nutrition2014
Inhibition of angiotensin-converting enzyme by aqueous extract of tomato.
Article in European journal of nutrition, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Platelet Aggregation Inhibition: An Evidence-Based Systematic Review on the Role of Herbs for Primary Prevention Based on Randomized Controlled Trials.Iranian journal of medical sciences · 2022Pooled it
- Phytochemical and Biological Biodiversity of Tomato (Mini reviews in medicinal chemistry · 2025Review
- Review
- The effect of water-soluble tomato concentrate on elevated serum cholesterol in the middle-aged and elderly Chinese individuals.Frontiers in nutrition · 2024Article
- Effects of Aqueous Extract ofPathophysiology : the official journal of the International Society for Pathophysiology · 2021Article
- Water-Soluble Tomato Extract Fruitflow Alters the Phosphoproteomic Profile of Collagen-Stimulated Platelets.Frontiers in pharmacology · 2021Article
- Chemical Characterisation and Antihypertensive Effects of Locular Gel and Serum ofMolecules (Basel, Switzerland) · 2020Article
- Standardised tomato extract as an alternative to acetylsalicylic acid in patients with primary hypertension and high cardiovascular risk - a randomised, controlled trial.Archives of medical science : AMS · 2018Article
- The influence of adding tomato extract and acetylsalicylic acid to hypotensive therapy on the daily blood pressure profiles of patients with arterial hypertension and high cardiovascular risk.Kardiochirurgia i torakochirurgia polska = Polish journal of cardio-thoracic surgery · 2017Article
- Antiplatelet treatment in the primary prophylaxis of cardiovascular disease in patients with arterial hypertension.Kardiochirurgia i torakochirurgia polska = Polish journal of cardio-thoracic surgery · 2017Review
- FruitflowEuropean journal of nutrition · 2017Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo investigate the presence of anti-angiotensin converting enzyme (ACE) factors in aqueous extract of tomato.
methodsThe bio-guided fractionation of the aqueous extract of tomato produced a sugar-free, heat-stable fraction with molecular mass <1,000 Da from tomatoes. The sugar-free tomato extract (TE) was tested for its anti-ACE activity using human plasma and rabbit lung pure ACE. In addition, its effect on human platelet aggregation induced by ADP, collagen or arachidonic acid was determined. The mechanism of platelet inhibitory action of TE was investigated by measuring platelet factor 4 (PF4) release and cAMP synthesis by platelets.
resultsTypically, 100 g tomatoes produced 72.2 ± 4.7 mg of TE. This extract inhibited both platelet aggregation and plasma ACE activity in a dose-dependent manner. It inhibited platelet aggregation in response to ADP, collagen or arachidonic acid, and inhibitory action was mediated in part by reducing platelet PF4 release and by stimulating cAMP synthesis. The IC50 value of TE for ADP-induced platelet aggregation was 0.4 ± 0.02 mg/ml, whereas the IC50 value for ACE enzyme inhibition was 1.40 ± 0.04 mg/ml. Both the TE and commercially available sugar-free TE, Fruitflow(®)-2 had similar amount of catechin, and also had equal inhibitory potencies against platelet aggregation and plasma ACE activity.
conclusionTogether these data indicate that aqueous extract of tomatoes contain anti-ACE factors in addition to previously described anti-platelet factors.
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