ArticleKidney international2014
Relation between BK-α/β4-mediated potassium secretion and ENaC-mediated sodium reabsorption.
Article in Kidney international, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 23 citations in OpenAlex.
- Novel Roles of GPCRs in the Renal Collecting Duct.Physiology (Bethesda, Md.) · 2026Review
- The exquisite link between potassium homeostasis regulation and cardiovascular health: exploration and analysis.Frontiers in physiology · 2026Review
- Cell Settling, Migration, and Stochastic Cancer Gene Expression Suggest Potassium Membrane Flux May Initiate pH Reversal.Biomolecules · 2025Article
- Collecting duct renin regulates potassium homeostasis in mice.Acta physiologica (Oxford, England) · 2023Article
- Mutation affecting the conserved acidic WNK1 motif causes inherited hyperkalemic hyperchloremic acidosis.The Journal of clinical investigation · 2020Article
- Renal NaAmerican journal of physiology. Renal physiology · 2019Article
- Furosemide reduces BK-αβ4-mediated KAmerican journal of physiology. Renal physiology · 2019Article
- Improved protocols for the study of urinary electrolyte excretion and blood pressure in rodents: use of gel food and stepwise changes in diet composition.American journal of physiology. Renal physiology · 2018Article
- Beneficial Effects of High Potassium: Contribution of Renal Basolateral KHypertension (Dallas, Tex. : 1979) · 2018Review
- Article
- Severe hyperkalemia is rescued by low-potassium diet in renal βENaC-deficient mice.Pflugers Archiv : European journal of physiology · 2017Article
- Net KKidney international · 2017Article
- Role and mechanisms of regulation of the basolateral KActa physiologica (Oxford, England) · 2017Review
- Maintaining KAmerican journal of physiology. Renal physiology · 2016Review
- Article
- Deficient acid handling with distal RTA in the NBCe2 knockout mouse.American journal of physiology. Renal physiology · 2015Article
- Increased Epithelial Sodium Channel Activity Contributes to Hypertension Caused by Na+-HCO3- Cotransporter Electrogenic 2 Deficiency.Hypertension (Dallas, Tex. : 1979) · 2015Article
- Cesium-associated hypokalemia successfully treated with amiloride.Clinical kidney journal · 2015Article
- Dietary potassium and the renal control of salt balance and blood pressure.Pflugers Archiv : European journal of physiology · 2015Review
- Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
The large-conductance, calcium-activated BK-α/β4 potassium channel, localized to the intercalated cells of the distal nephron, mediates potassium secretion during high-potassium, alkaline diets. Here we determine whether BK-α/β4-mediated potassium transport is dependent on epithelial sodium channel (ENaC)-mediated sodium reabsorption. We maximized sodium-potassium exchange in the distal nephron by feeding mice a low-sodium, high-potassium diet. Wild-type and BK-β4 knockout mice were maintained on a low-sodium, high-potassium, alkaline diet or a low-sodium, high-potassium, acidic diet for 7-10 days. Wild-type mice maintained potassium homeostasis on the alkaline, but not acid, diet. BK-β4 knockout mice could not maintain potassium homeostasis on either diet. During the last 12 h of diet, wild-type mice on either a regular, alkaline, or an acid diet, or knockout mice on an alkaline diet, were administered amiloride (an ENaC inhibitor). Amiloride enhanced sodium excretion in all wild-type and knockout groups to similar values; however, amiloride diminished potassium excretion by 59% in wild-type but only by 33% in knockout mice on an alkaline diet. Similarly, amiloride decreased the trans-tubular potassium gradient by 68% in wild-type but only by 42% in knockout mice on an alkaline diet. Amiloride treatment equally enhanced sodium excretion and diminished potassium secretion in knockout mice on an alkaline diet and wild-type mice on an acid diet. Thus, the enhanced effect of amiloride on potassium secretion in wild-type compared to knockout mice on the alkaline diet clarify a BK- α/β4-mediated potassium secretory pathway in intercalated cells driven by ENaC-mediated sodium reabsorption linked to bicarbonate secretion.
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