ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2014
Transduction for pheromones in the main olfactory epithelium is mediated by the Ca2+ -activated channel TRPM5.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 47 citations in OpenAlex.
- A microbiome-derived olfactory signal regulates inter-male aggression and social dominance in mice.Current biology : CB · 2026Article
- The TRP channels serving as chemical-to-electrical signal converter.Physiological reviews · 2025Review
- The TRPM5 Antagonist Triphenylphosphine Oxide Increases Sebaceous Lipogenesis and Modulates Immune Phenotype of Human Sebocytes in a TRPM5-Independent Manner.Experimental dermatology · 2025Article
- From In Vitro Data to In Vivo Interspecies Danger Communication: A Study of Chemosensing via the Mouse Grueneberg Ganglion.Animals : an open access journal from MDPI · 2022Article
- Transcriptional profiling reveals potential involvement of microvillous TRPM5-expressing cells in viral infection of the olfactory epithelium.BMC genomics · 2021Article
- Coding of pheromones by vomeronasal receptors.Cell and tissue research · 2021Review
- Article
- Expressed Vomeronasal Type-1 Receptors (V1rs) in Bats Uncover Conserved Sequences Underlying Social Chemical Signaling.Genome biology and evolution · 2019Article
- Differential Expression of Mucins in Murine Olfactory Versus Respiratory Epithelium.Chemical senses · 2019Article
- Article
- Second messenger molecules have a limited spread in olfactory cilia.The Journal of general physiology · 2018Article
- Vomeronasal and Olfactory Structures in Bats Revealed by DiceCT Clarify Genetic Evidence of Function.Frontiers in neuroanatomy · 2018Article
- ATP and Odor Mixture Activate TRPM5-Expressing Microvillous Cells and Potentially Induce Acetylcholine Release to Enhance Supporting Cell Endocytosis in Mouse Main Olfactory Epithelium.Frontiers in cellular neuroscience · 2018Article
- Dichotomous Distribution of Putative Cholinergic Interneurons in Mouse Accessory Olfactory Bulb.Frontiers in neuroanatomy · 2017Article
- Mammalian pheromones: emerging properties and mechanisms of detection.Current opinion in neurobiology · 2015Review
- Ion transporter NKCC1, modulator of neurogenesis in murine olfactory neurons.The Journal of biological chemistry · 2015Article
- Molecular evidence for the loss of three basic tastes in penguins.Current biology : CB · 2015Article
- Genetic dissection of pheromone processing reveals main olfactory system-mediated social behaviors in mice.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- CD36 is involved in oleic acid detection by the murine olfactory system.Frontiers in cellular neuroscience · 2015Article
- Neuregulin1 and ErbB expression in the uninjured and regenerating olfactory mucosa.Gene expression patterns : GEPArticle
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Growing evidence suggests that the main olfactory epithelium contains a subset of olfactory sensory neurons (OSNs) responding to pheromones. One candidate subpopulation expresses the calcium activated cation channel TRPM5 (transient receptor potential channel M5). Using GFP driven by the TRPM5 promoter in mice, we show that this subpopulation responds to putative pheromones, urine, and major histocompatibility complex peptides, but not to regular odors or a pheromone detected by other species. In addition, this subpopulation of TRPM5-GFP+ OSNs uses novel transduction. In regular OSNs, odorants elicit activation of the cyclic nucleotide-gated (CNG) channel, leading to Ca2+ gating of Cl- channels; in TRPM5-GFP+ OSNs, the Ca2+ -activated Cl- ANO2 (anoctamin 2) channel is not expressed, and pheromones elicit activation of the CNG channel leading to Ca2+ gating of TRPM5. In conclusion, we show that OSNs expressing TRPM5 respond to pheromones, but not to regular odors through the opening of CNG channels leading to Ca2+ gating of TRPM5.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.