ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2014
Large somatic synapses on neurons in the ventral lateral lemniscus work in pairs.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 31 citations in OpenAlex.
- An anatomical and physiological basis for flexible coincidence detection in the auditory system.eLife · 2025Article
- Cellular and synaptic specializations for sub-millisecond precision in the mammalian auditory brainstem.Frontiers in cellular neuroscience · 2025Review
- Anatomy of superior olivary complex and lateral lemniscus in Etruscan shrew.Scientific reports · 2024Article
- Neuronal morphology and synaptic input patterns of neurons in the intermediate nucleus of the lateral lemniscus of gerbils.Scientific reports · 2023Article
- The role of GABAFrontiers in endocrinology · 2023Review
- Presynaptic voltage-gated calcium channels in the auditory brainstem.Molecular and cellular neurosciences · 2021Review
- Information Processing by Onset Neurons in the Cat Auditory Brainstem.Journal of the Association for Research in Otolaryngology : JARO · 2020Article
- Minimal Number of Required Inputs for Temporally Precise Action Potential Generation in Auditory Brainstem Nuclei.Frontiers in cellular neuroscience · 2020Article
- The Calyx of Held: A Hypothesis on the Need for Reliable Timing in an Intensity-Difference Encoder.Neuron · 2018Review
- Cellular Computations Underlying Detection of Gaps in Sounds and Lateralizing Sound Sources.Trends in neurosciences · 2017Review
- Perinatal nicotine exposure impairs the maturation of glutamatergic inputs in the auditory brainstem.The Journal of physiology · 2017Article
- Genetic perturbations suggest a role of the resting potential in regulating the expression of the ion channels of the KCNA and HCN families in octopus cells of the ventral cochlear nucleus.Hearing research · 2017Article
- Octopus Cells in the Posteroventral Cochlear Nucleus Provide the Main Excitatory Input to the Superior Paraolivary Nucleus.Frontiers in neural circuits · 2017Article
- Presynaptic hyperpolarization induces a fast analogue modulation of spike-evoked transmission mediated by axonal sodium channels.Nature communications · 2015Article
- Decreased temporal precision of neuronal signaling as a candidate mechanism of auditory processing disorder.Hearing research · 2015Review
- Heterogeneity of Intrinsic and Synaptic Properties of Neurons in the Ventral and Dorsal Parts of the Ventral Nucleus of the Lateral Lemniscus.Frontiers in neural circuits · 2015Article
- The relative contributions of MNTB and LNTB neurons to inhibition in the medial superior olive assessed through single and paired recordings.Frontiers in neural circuits · 2014Article
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4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the auditory system, large somatic synapses convey strong excitation that supports temporally precise information transfer. The information transfer of such synapses has predominantly been investigated in the endbulbs of Held in the anterior ventral cochlear nucleus and the calyx of Held in the medial nucleus of the trapezoid body. These large synapses either work as relays or integrate over a small number of inputs to excite the postsynaptic neuron beyond action potential (AP) threshold. In the monaural system, another large somatic synapse targets neurons in the ventral nucleus of the lateral lemniscus (VNLL). Here, we comparatively analyze the mechanisms of synaptic information transfer in endbulbs in the VNLL and the calyx of Held in juvenile Mongolian gerbils. We find that endbulbs in the VNLL are functionally surface-scaled versions of the calyx of Held with respect to vesicle availability, release efficacy, and synaptic peak currents. This functional scaling is achieved by different calcium current kinetics that compensate for the smaller AP in VNLL endbulbs. However, the average postsynaptic current in the VNLL fails to elicit APs in its target neurons, even though equal current suffices to generate APs in neurons postsynaptic to the calyx of Held. In the VNLL, a postsynaptic A-type outward current reduces excitability and prevents AP generation upon a single presynaptic input. Instead, coincidence detection of inputs from two converging endbulbs is ideal to reliably trigger APs. Thus, even large endbulbs do not guarantee one-to-one AP transfer. Instead, information flow appears regulated by circuit requirements.
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