ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2014
Neuropeptidergic signaling partitions arousal behaviors in zebrafish.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
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Who cites it
58 citing papers in PubMed.
- Disinhibition of cerebellar output by loss of restless legs syndrome-associated gene MEIS1.Current biology : CB · 2026Article
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- Characterization of Transgenic Lines Labeling Reticulospinal Neurons in Larval Zebrafish.eNeuro · 2025Article
- Context-dependent hyperactivity inFrontiers in molecular neuroscience · 2024Article
- SAMPL is a high-throughput solution to study unconstrained vertical behavior in small animals.Cell reports · 2023Article
- Scalable Apparatus to Measure Posture and Locomotion (SAMPL): a high-throughput solution to study unconstrained vertical behavior in small animals.bioRxiv : the preprint server for biology · 2023Article
- Roles of Neuropeptides in Sleep-Wake Regulation.International journal of molecular sciences · 2022Review
- Larval Zebrafish as a Model for Mechanistic Discovery in Mental Health.Frontiers in molecular neuroscience · 2022Review
- Validation of Candidate Sleep Disorder Risk Genes Using Zebrafish.Frontiers in molecular neuroscience · 2022Review
- Osmotic Stress Uncovers Correlations and Dissociations Between Larval Zebrafish Anxiety Endophenotypes.Frontiers in molecular neuroscience · 2022Article
- Conservation of mechanisms regulating emotional-like responses on spontaneous nicotine withdrawal in zebrafish and mammals.Progress in neuro-psychopharmacology & biological psychiatry · 2021Article
- The habenula clock influences response to a stressor.Neurobiology of stress · 2021Article
- Genetic determinants of daytime napping and effects on cardiometabolic health.Nature communications · 2021Article
- Neuromodulation and Behavioral Flexibility in Larval Zebrafish: From Neurotransmitters to Circuits.Frontiers in molecular neuroscience · 2021Article
- A Chromosome-Level Genome Assembly of the Mandarin Fish (Frontiers in genetics · 2021Article
- Article
- Marijuana and Opioid Use during Pregnancy: Using Zebrafish to Gain Understanding of Congenital Anomalies Caused by Drug Exposure during Development.Biomedicines · 2020Review
- A Customizable Low-Cost System for Massively Parallel Zebrafish Behavioral Phenotyping.Frontiers in behavioral neuroscience · 2020Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Animals modulate their arousal state to ensure that their sensory responsiveness and locomotor activity match environmental demands. Neuropeptides can regulate arousal, but studies of their roles in vertebrates have been constrained by the vast array of neuropeptides and their pleiotropic effects. To overcome these limitations, we systematically dissected the neuropeptidergic modulation of arousal in larval zebrafish. We quantified spontaneous locomotor activity and responsiveness to sensory stimuli after genetically induced expression of seven evolutionarily conserved neuropeptides, including adenylate cyclase activating polypeptide 1b (adcyap1b), cocaine-related and amphetamine-related transcript (cart), cholecystokinin (cck), calcitonin gene-related peptide (cgrp), galanin, hypocretin, and nociceptin. Our study reveals that arousal behaviors are dissociable: neuropeptide expression uncoupled spontaneous activity from sensory responsiveness, and uncovered modality-specific effects upon sensory responsiveness. Principal components analysis and phenotypic clustering revealed both shared and divergent features of neuropeptidergic functions: hypocretin and cgrp stimulated spontaneous locomotor activity, whereas galanin and nociceptin attenuated these behaviors. In contrast, cart and adcyap1b enhanced sensory responsiveness yet had minimal impacts on spontaneous activity, and cck expression induced the opposite effects. Furthermore, hypocretin and nociceptin induced modality-specific differences in responsiveness to changes in illumination. Our study provides the first systematic and high-throughput analysis of neuropeptidergic modulation of arousal, demonstrates that arousal can be partitioned into independent behavioral components, and reveals novel and conserved functions of neuropeptides in regulating arousal.
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