ReviewAmerican journal of physiology. Regulatory, integrative and comparative physiology2014
Remembering to eat: hippocampal regulation of meal onset.
Review in American journal of physiology. Regulatory, integrative and comparative physiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed.
- Trial
- Top-down regulation of ingestive behavior fragmentation.bioRxiv : the preprint server for biology · 2026Article
- Consumption of a diet high in fat and sugar is associated with worse spatial navigation ability in a virtual environment.International journal of obesity (2005) · 2025Article
- The sex-specific relationship of ghrelin and cognition in Chinese han first-episode drug-naive major depressive disorder.Journal of neural transmission (Vienna, Austria : 1996) · 2025Article
- Association of Diet and Waist-to-Hip Ratio With Brain Connectivity and Memory in Aging.JAMA network open · 2025Article
- How is the brain affected by metabolically healthy or unhealthy obesity in adulthood and elderly? A narrative review of neuroimaging and neurocognitive findings.Frontiers in aging neuroscience · 2025Review
- Hunger, Satiety, and Their Vulnerabilities.Nutrients · 2024Review
- Chronic Semaglutide Treatment in Rats Leads to Daily Excessive Concentration-Dependent Sucrose Intake.Journal of the Endocrine Society · 2023Article
- Dynamic regulation of the extracellular matrix in reward memory processes: a question of time.Frontiers in cellular neuroscience · 2023Review
- A new apparatus to analyze meal-related ingestive behaviors in rats fed a complex multi-food diet.Physiology & behavior · 2022Article
- Using structural equation modeling to understand family and psychological factors of childhood obesity: from socioeconomic disadvantage to loss of control eating.Eating and weight disorders : EWD · 2022Article
- Maternal Diabetes and Postnatal High-Fat Diet on Pregnant Offspring.Frontiers in cell and developmental biology · 2022Article
- Do hippocampal pyramidal cells respond to nonspatial stimuli?Physiological reviews · 2021Review
- Ghrelin and Orexin Interact to Increase Meal Size Through a Descending Hippocampus to Hindbrain Signaling Pathway.Biological psychiatry · 2020Article
- Legend of Weight Loss: a Crosstalk Between the Bariatric Surgery and the Brain.Obesity surgery · 2020Review
- Western Diet: Implications for Brain Function and Behavior.Frontiers in psychology · 2020Review
- Regulation of Memory Function by Feeding-Relevant Biological Systems: Following the Breadcrumbs to the Hippocampus.Frontiers in molecular neuroscience · 2019Review
- Effects of Maternal and Post-Weaning High-Fat Diet on Leptin Resistance and Hypothalamic Appetite Genes in Sprague Dawley Rat Offspring.Clinical nutrition research · 2018Article
- Homeostatic and non-homeostatic controls of feeding behavior: Distinct vs. common neural systems.Physiology & behavior · 2018Review
- A hippocampus to prefrontal cortex neural pathway inhibits food motivation through glucagon-like peptide-1 signaling.Molecular psychiatry · 2018 · on this mapArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A wide variety of species, including vertebrate and invertebrates, consume food in bouts (i.e., meals). Decades of research suggest that different mechanisms regulate meal initiation (when to start eating) versus meal termination (how much to eat in a meal, also known as satiety). There is a very limited understanding of the mechanisms that regulate meal onset and the duration of the postprandial intermeal interval (ppIMI). In the present review, we examine issues involved in measuring meal onset and some of the limited available evidence regarding how it is regulated. Then, we describe our recent work indicating that dorsal hippocampal neurons inhibit meal onset during the ppIMI and describe the processes that may be involved in this. We also synthesize recent evidence, including evidence from our laboratory, suggesting that overeating impairs hippocampal functioning and that impaired hippocampal functioning, in turn, contributes to the development and/or maintenance of diet-induced obesity. Finally, we identify critical questions and challenges for future research investigating neural controls of meal onset.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.