ArticlePlastic and reconstructive surgery2014
Deferoxamine enhances bone regeneration in mandibular distraction osteogenesis.
Article in Plastic and reconstructive surgery, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 39 citations in OpenAlex.
- Cyclic distraction-compression promotes bone regeneration during distraction osteogenesis through the Piezo1-YAP-β-catenin axis.Frontiers in bioengineering and biotechnology · 2026Article
- Deferoxamine improves femoral trochlear dysplasia following patellar dislocation through HIF-1α/VEGF-mediated angiogenesis-osteogenesis coupling.Journal of orthopaedic surgery and research · 2025Article
- Advanced therapeutic scaffolds of biomimetic periosteum for functional bone regeneration.Journal of nanobiotechnology · 2025Review
- Importance of bone health in bone lengthening.Journal of the Pediatric Orthopaedic Society of North America · 2024Article
- Application of Deferoxamine in Tissue Regeneration Attributed to Promoted Angiogenesis.Molecules (Basel, Switzerland) · 2024Review
- Application of chemical factors for acceleration of consolidation phase of the distraction osteogenesis: a scoping review.Oral and maxillofacial surgery · 2023Article
- Review on Additives in Hydrogels for 3D Bioprinting of Regenerative Medicine: From Mechanism to Methodology.Pharmaceutics · 2023Review
- Overview of Physical and Pharmacological Therapy in Enhancing Bone Regeneration Formation During Distraction Osteogenesis.Frontiers in cell and developmental biology · 2022Review
- Hypoxia During the Consolidation Phase of Distraction Osteogenesis Promotes Bone Regeneration.Frontiers in physiology · 2022Article
- [Early constant observation of the effect of deferoxamine mesylate on improvement of vascularized bone regeneration in SD rat skull critical size defect model].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2021Article
- Experimental study of the effects of hypoxia simulator on osteointegration of titanium prosthesis in osteoporotic rats.BMC musculoskeletal disorders · 2021Article
- Implantable hyaluronic acid-deferoxamine conjugate prevents nonunions through stimulation of neovascularization.NPJ Regenerative medicine · 2019Article
- Topical Deferoxamine Alleviates Skin Injury and Normalizes Atomic Force Microscopy Patterns Following Radiation in a Murine Breast Reconstruction Model.Annals of plastic surgery · 2018Article
- Deferoxamine Preconditioning of Irradiated Tissue Improves Perfusion and Fat Graft Retention.Plastic and reconstructive surgery · 2018Article
- Synergistic protection of bone vasculature and bone mass by desferrioxamine in osteoporotic mice.Molecular medicine reports · 2017Article
- Significant Differences in the Bone of an Isogenic Inbred Versus Nonisogenic Outbred Murine Mandible: A Study in Rigor and Reproducibility.The Journal of craniofacial surgery · 2017Article
- Human fetal mesenchymal stem cell secretome enhances bone consolidation in distraction osteogenesis.Stem cell research & therapy · 2016Article
- Clinical Use of Deferoxamine in Distraction Osteogenesis of Irradiated Bone.The Journal of craniofacial surgery · 2016Article
- An Update on Midface Advancement Using Le Fort II and III Distraction Osteogenesis.Seminars in plastic surgery · 2014Article
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Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
backgroundDistraction osteogenesis is a powerful reconstructive technique for bone growth and repair. An angiogenic means of enhancing the efficacy of this metabolically demanding procedure would be beneficial in expanding its therapeutic potential. The authors posit that the angiogenic effect of deferoxamine, an iron chelator that has been shown to increase angiogenesis, will improve bone regeneration by means of augmentations in quality and quantity of bone and bone-producing cells.
methodsTwo groups of rats (n = 12) underwent surgical external fixation and subsequent distraction. During the distraction stage, the experimental deferoxamine group (n = 5) was treated with injections into the distraction gap. After 28 days of consolidation, mandibles were harvested and prepared for histologic analysis.
resultsThe authors found a proliferation of osteocytes in the deferoxamine-treated group when compared with the regenerate of the control group. Deferoxamine effected a significant increase in osteocytes and an increase in bone volume fraction, with subsequent decreased osteoid volume fraction. The data also demonstrated no significant difference in empty lacunae.
conclusionsThe authors' study demonstrates the effectiveness of deferoxamine treatment to enhance the number of osteocytes within the regenerate in a murine mandibular distraction osteogenesis model. Maintenance of full lacunae supports the authors' finding of a robust cellular response to deferoxamine therapy. These results suggest that the angiogenic capabilities of deferoxamine translate into an increase in the number of bone-forming cells in the regenerate. Deferoxamine may have utility in optimizing bone formation in distraction osteogenesis and lead to superior reconstructive capabilities for craniofacial surgeons in the future.
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Registered trials
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