Evidence map›Paper›PMID 24572742›Full record

ArticleGenes and immunity2014

Family studies of type 1 diabetes reveal additive and epistatic effects between MGAT1 and three other polymorphisms.

Z Yu, C F Li, H Mkhikian, R W Zhou, B L Newton, M Demetriou

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes and immunity, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.7field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 18 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Microbiome signatures of progression toward celiac disease onset in at-risk children in a longitudinal prospective cohort study.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  6. Article
  7. Article
  8. Article
  9. The Modulatory Roles of N-glycans in T-Cell-Mediated Autoimmune Diseases.International journal of molecular sciences · 2018
    Review
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Z YuDepartment of Statistics, University of California, Irvine, CA, USA.
C F Li1] Department of Neurology, University of California, Irvine, CA, USA [2] Institute for Immunology, University of California, Irvine, CA, USA.
H MkhikianDepartment of Microbiology & Molecular Genetics, University of California, Irvine, CA, USA.
R W ZhouDepartment of Microbiology & Molecular Genetics, University of California, Irvine, CA, USA.
B L NewtonDepartment of Neurology, University of California, Irvine, CA, USA.
M Demetriou1] Department of Neurology, University of California, Irvine, CA, USA [2] Institute for Immunology, University of California, Irvine, CA, USA [3] Department of Microbiology & Molecular Genetics, University of California, Irvine, CA, USA.
University of California, Irvine · US

Funding

Human Autoimmunity and Genetic Defects in N-GlycosylationR01AI082266 · NIAID · UNIVERSITY OF CALIFORNIA-IRVINE · PI DEMETRIOU, MICHAEL · 2010 to 2013
$1.5M
Improving genotype call accuracyR01HG004960 · NHGRI · UNIVERSITY OF WASHINGTON · PI BROWNING, BRIAN LEE · 2009 to 2014
$1.4M
NHGRI NIH HHS R01 HG004960NHGRI NIH HHS R01HG004960NIAID NIH HHS R01 AI082266NIAID NIH HHS R01AI082266
6 · The paper itself

Abstract

In a recent study on multiple sclerosis (MS), we observed additive effects and epistatic interactions between variants of four genes that converge to induce T-cell hyperactivity by altering Asn-(N)-linked protein glycosylation: namely, the Golgi enzyme MGAT1, cytotoxic T-lymphocyte antigen 4 (CTLA-4), interleukin-2 receptor-α (IL2RA) and interleukin-7 receptor-α (IL7RA). As the CTLA-4, IL2RA and IL7RA variants are associated with type 1 diabetes (T1D), we examined for joint effects in T1D. Employing a novel conditional logistic regression for family-based data sets, epistatic and additive effects were observed using 1423 multiplex families from the Type 1 Diabetes Genetic Consortium data set. The IL2RA and IL7RA variants had univariate association in MS and T1D, whereas the MGAT1 and CTLA-4 variants associated with only MS or T1D, respectively. However, similar to MS, the MGAT1 variant haplotype interacted with CTLA4 (P=0.03), and a combination of IL2RA and IL7RA (P=0.01). The joint effects of MGAT1, CTLA4, IL2RA, IL7RA and the two interactions using a multiple conditional logistic regression were statistically highly significant (P<5 × 10(-10)). The MGAT1-CTLA-4 interaction was replicated (P=0.01) in 179 trio families from the Genetics of Kidneys in Diabetes study. These data are consistent with defective N-glycosylation of T cells contributing to T1D pathogenesis.

Indexed as

Epistasis, GeneticFamilyCTLA-4 AntigenDatasets as TopicDiabetes Mellitus, Type 1FemaleGenetic VariationHumansInterleukin-2 Receptor alpha SubunitMaleN-AcetylglucosaminyltransferasesReceptors, Interleukin-7CTLA-4 AntigenCTLA4 protein, humanIL2RA protein, humanInterleukin-2 Receptor alpha SubunitMGAT1 protein, humanN-AcetylglucosaminyltransferasesReceptors, Interleukin-7

Identifiers

PMID24572742
PMCPMC4047175
OpenAlexW1974045071

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.