ArticleJournal of neurophysiology2014
Disturbances of motor unit rate modulation are prevalent in muscles of spastic-paretic stroke survivors.
Article in Journal of neurophysiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 66 citations in OpenAlex.
- Longitudinal assessment of lower limb muscle quantity and quality in acute stroke patients.Journal of rehabilitation medicine · 2026Observational
- Pathophysiology of voluntary motor commands at the level of the spinal motoneuron in patients with multiple sclerosis.medRxiv : the preprint server for health sciences · 2025Article
- The Effects of Transcranial Direct Current Stimulation During Extended Reality Exercises for Cortical, Neuromuscular, and Clinical Recovery of Stroke Survivors.Neural plasticity · 2025Article
- Article
- Pedaling Asymmetry Reflected by Bilateral EMG Complexity in Chronic Stroke.Entropy (Basel, Switzerland) · 2024Article
- Lower extremity muscle activity during reactive balance differs between adults with chronic traumatic brain injury and controls.Frontiers in neurology · 2024Article
- Motor unit firing rate modulation is more impaired during flexion synergy-driven contractions of the biceps brachii in chronic stroke.medRxiv : the preprint server for health sciences · 2023Article
- Compound muscle action potential (CMAP) scan examination of paretic and contralateral muscles reveals motor unit alterations after stroke.Science China. Life sciences · 2023Article
- Fundamental Concepts of Bipolar and High-Density Surface EMG Understanding and Teaching for Clinical, Occupational, and Sport Applications: Origin, Detection, and Main Errors.Sensors (Basel, Switzerland) · 2022Review
- Electrical Properties of Adult Mammalian Motoneurons.Advances in neurobiology · 2022Article
- Longer electromechanical delay in paretic triceps surae muscles during voluntary isometric plantarflexion torque generation in chronic hemispheric stroke survivors.Journal of electromyography and kinesiology : official journal of the International Society of Electrophysiological Kinesiology · 2021Article
- Wireless Sensing of Lower Lip and Thumb-Index Finger 'Ramp-and-Hold' Isometric Force Dynamics in a Small Cohort of Unilateral MCA Stroke: Discussion of Preliminary Findings.Sensors (Basel, Switzerland) · 2020Article
- Effects of Changes in Ankle Joint Angle on the Relation Between Plantarflexion Torque and EMG Magnitude in Major Plantar Flexors of Male Chronic Stroke Survivors.Frontiers in neurology · 2020Article
- Dynamic bimanual force control in chronic stroke: contribution of non-paretic and paretic hands.Experimental brain research · 2019Article
- Coupling Robot-Aided Assessment and Surface Electromyography (sEMG) to Evaluate the Effect of Muscle Fatigue on Wrist Position Sense in the Flexion-Extension Plane.Frontiers in human neuroscience · 2019Article
- Stroke increases ischemia-related decreases in motor unit discharge rates.Journal of neurophysiology · 2018Article
- The potential for understanding the synaptic organization of human motor commands via the firing patterns of motoneurons.Journal of neurophysiology · 2017Review
- Synaptic control of the shape of the motoneuron pool input-output function.Journal of neurophysiology · 2017Article
- Motor Unit Activity during Fatiguing Isometric Muscle Contraction in Hemispheric Stroke Survivors.Frontiers in human neuroscience · 2017Article
- Altered Motor Unit Discharge Coherence in Paretic Muscles of Stroke Survivors.Frontiers in neurology · 2017Article
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Stroke survivors often exhibit abnormally low motor unit firing rates during voluntary muscle activation. Our purpose was to assess the prevalence of saturation in motor unit firing rates in the spastic-paretic biceps brachii muscle of stroke survivors. To achieve this objective, we recorded the incidence and duration of impaired lower- and higher-threshold motor unit firing rate modulation in spastic-paretic, contralateral, and healthy control muscle during increases in isometric force generated by the elbow flexor muscles. Impaired firing was considered to have occurred when firing rate became constant (i.e., saturated), despite increasing force. The duration of impaired firing rate modulation in the lower-threshold unit was longer for spastic-paretic (3.9 ± 2.2 s) than for contralateral (1.4 ± 0.9 s; P < 0.001) and control (1.1 ± 1.0 s; P = 0.005) muscles. The duration of impaired firing rate modulation in the higher-threshold unit was also longer for the spastic-paretic (1.7 ± 1.6 s) than contralateral (0.3 ± 0.3 s; P = 0.007) and control (0.1 ± 0.2 s; P = 0.009) muscles. This impaired firing rate of the lower-threshold unit arose, despite an increase in the overall descending command, as shown by the recruitment of the higher-threshold unit during the time that the lower-threshold unit was saturating, and by the continuous increase in averages of the rectified EMG of the biceps brachii muscle throughout the rising phase of the contraction. These results suggest that impairments in firing rate modulation are prevalent in motor units of spastic-paretic muscle, even when the overall descending command to the muscle is increasing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.