ArticleBiology of reproduction2014
Epigenetics of human myometrium: DNA methylation of genes encoding contraction-associated proteins in term and preterm labor.
Article in Biology of reproduction, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 39 citations in OpenAlex.
- Racial and ethnic representation in epigenomic studies of preterm birth: a systematic review.Epigenomics · 2021Pooled it
- A Systematic Review of DNA Methylation and Preterm Birth in African American Women.Biological research for nursing · 2017Pooled it
- Exploring the role of epigenetics in the processes related to the development of endometrosis in the mare.The Journal of reproduction and development · 2026Review
- Assessment of the histone mark-based epigenomic landscape in human myometrium at term pregnancy.eLife · 2025Article
- Deciphering maternal-fetal cross-talk in the human placenta during parturition using single-cell RNA sequencing.Science translational medicine · 2024Article
- The Role of Genetics in Preterm Birth.Reproductive sciences (Thousand Oaks, Calif.) · 2023Review
- Oxytocin receptor DNA methylation is associated with exogenous oxytocin needs during parturition and postpartum hemorrhage.Communications medicine · 2023Article
- Birth, love, and fear: Physiological networks from pregnancy to parenthood.Comprehensive psychoneuroendocrinology · 2022Review
- A single-cell atlas of the myometrium in human parturition.JCI insight · 2022Article
- Transcriptome changes in maternal peripheral blood during term parturition mimic perturbations preceding spontaneous preterm birth†.Biology of reproduction · 2022Article
- Advancing understanding of maternal age: correlating epigenetic clocks in blood and myometrium.Epigenetics communications · 2022Article
- Genomic and molecular characterization of preterm birth.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Analysis of two birth tissues provides new insights into the epigenetic landscape of neonates born preterm.Clinical epigenetics · 2019Observational
- Comparison of DNA methylation profiles associated with spontaneous preterm birth in placenta and cord blood.BMC medical genomics · 2019Article
- Differential expression and methylation of integrin subunit alpha 11 and thrombospondin in the amnion of preterm birth.Obstetrics & gynecology science · 2018Article
- Effect of molecular hydrogen on uterine inflammation during preterm labour.Biomedical reports · 2018Article
- Alterations in the placental methylome with maternal obesity and evidence for metabolic regulation.PloS one · 2017Article
- The genomics of prematurity in an era of more precise clinical phenotyping: A review.Seminars in fetal & neonatal medicine · 2016Review
- Epigenetics-a potential mediator between air pollution and preterm birth.Environmental epigenetics · 2016Article
- Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Preterm birth involves the interaction of societal and environmental factors potentially modulating the length of gestation via the epigenome. An established form of epigenetic regulation is DNA methylation where promoter hypermethylation is associated with gene repression. We hypothesized we would find differences in DNA methylation in the myometrium of women with preterm labor of different phenotypes versus normal term labor. Myometrial tissue was obtained at cesarean section at term with or without labor, preterm without labor, idiopathic preterm labor, and twin gestations with labor. Genomic DNA was isolated, and samples in each group were combined and analyzed on a NimbleGen 2.1M human DNA methylation array. Differences in methylation from -8 to +3 kb of transcription start sites of 22 contraction-associated genes were determined. Cytosine methylation was not present in CpG islands of any gene but was present outside of CpG islands in shores and shelves in 19 genes. No differential methylation was found across the tissue groups for six genes (PTGES3L, PTGER2, PTGER4, PTGFRN, ESR2, and GJA1). For 13 genes, differential methylation occurred in several patterns between tissue groups. We find a correlation between hypomethylation and increased mRNA expression of PTGES/mPGES-1, indicating potential functional relevance of methylation, but no such correlation for PTGS2/COX-2, suggesting other regulatory mechanisms for PTGS2 at labor. The majority of differential DNA methylation of myometrial contraction-associated genes with different labor phenotypes occurs outside of CpG islands in gene promoters, suggesting that the entirety of DNA methylation across the genome should be considered.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.