ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2014
Retinopathy in a novel model of metabolic syndrome and type 2 diabetes: new insight on the inflammatory paradigm.
Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 52 citations in OpenAlex.
- The Protective Effect of Topical PACAP38 in Retinal Morphology and Function of Type 2 Diabetic Retinopathy.International journal of molecular sciences · 2025Article
- Association of the apoptotic markers Apo1/Fas and cCK-18 and the adhesion molecule ICAM-1 with Type 1 diabetes mellitus in children and adolescents.BMC pediatrics · 2024Article
- Article
- Aquaporins contribute to vacuoles formation in Nile grass type II diabetic rats.Medical molecular morphology · 2023Article
- Immunological consequences of compromised ocular immune privilege accelerate retinal degeneration in retinitis pigmentosa.Orphanet journal of rare diseases · 2022Article
- Longer Interscan Times in OCT Angiography Detect Slower Capillary Flow in Diabetic Retinopathy.Ophthalmology science · 2022Article
- The innate immune system in diabetic retinopathy.Progress in retinal and eye research · 2021Review
- MicroRNAs may provide new strategies in the treatment and diagnosis of diabetic retinopathy: Importance of VEGF.Iranian journal of basic medical sciences · 2021Review
- Relationships among resistin, adiponectin, and leptin and microvascular complications in patients with type 2 diabetes mellitus.The Journal of international medical research · 2020Article
- New Insights Into Immunological Therapy for Retinal Disorders.Frontiers in immunology · 2020Review
- Palm Fruit Bioactives augment expression of Tyrosine Hydroxylase in the Nile Grass Rat basal ganglia and alter the colonic microbiome.Scientific reports · 2019Article
- Vascular changes in diabetic retinopathy-a longitudinal study in the Nile rat.Laboratory investigation; a journal of technical methods and pathology · 2019Article
- In contrast to Western diet, a plant-based, high-fat, low-sugar diet does not exacerbate retinal endothelial injury in streptozotocin-induced diabetes.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
- Genetic Permissiveness and Dietary Glycemic Load Interact to Predict Type-II Diabetes in the Nile rat (Nutrients · 2019Article
- Prostaglandin EDiabetologia · 2019Article
- The Nile Rat (Arvicanthis niloticus) as a Superior Carbohydrate-Sensitive Model for Type 2 Diabetes Mellitus (T2DM).Nutrients · 2018Review
- Forskolin attenuates retinal inflammation in diabetic mice.Molecular medicine reports · 2018Article
- Vascular Cell Adhesion Molecule 1, Intercellular Adhesion Molecule 1, and Cluster of Differentiation 146 Levels in Patients with Type 2 Diabetes with Complications.Endocrinology and metabolism (Seoul, Korea) · 2017Article
- Rho-Kinase/ROCK as a Potential Drug Target for Vitreoretinal Diseases.Journal of ophthalmology · 2017Review
- Functional Deficits Precede Structural Lesions in Mice With High-Fat Diet-Induced Diabetic Retinopathy.Diabetes · 2016Article
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Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The pathogenesis of diabetic retinopathy (DR) in metabolic syndrome (MetS) and type 2 diabetes (T2D) is not well studied, partly because an appropriate model has not been developed. Recently, we introduced a novel model of spontaneous T2D and MetS that replicates the relevant features of the human disease. In the current study, we investigated the retinal vascular changes in these animals. Experimental DR in streptozotocin (STZ)-injected rodents is described as an inflammatory disease, in which intercellular adhesion molecule 1 (ICAM-1) plays a key role. In comparison, advanced diabetes (HbA1c>10%) in the Nile grass rat (NGR) was associated with lower ICAM-1 protein expression when compared with that in normal or moderately diabetic animals. Vascular cell adhesion molecule 1 (VCAM-1) expression, however, was unaffected by the disease state. As opposed to the STZ-induced model of DR, in diabetic NGRs, most leukocytes accumulated in the retinal arteries. Consistent with the ICAM-1 reduction, leukocyte accumulation was significantly reduced in advanced disease. Similarly, leukocyte adhesions were significantly lower, with elevated plasma triglycerides (>200 mg/dl), and cholesterol (>240 mg/dl). However, these adhesions were significantly higher in animals with higher plasma insulin (>5 μIU/ml) and leptin (>20 ng/ml), suggesting a role for these hormones in diabetic retinal leukostasis. Diabetic NGRs showed substantial retinal endothelial injury, primarily in the microvessels, including vascular tortuosity, obliterated acellular capillaries, and pericyte ghosts. The NGR provides a convenient and realistic model for investigation of retinal changes in MetS/T2D with convincing advantages over the commonly used STZ-induced T1D.
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