Evidence map›Paper›PMID 24571913›Full record

ArticleRadiation oncology (London, England)2014

Evaluation of volumetric modulated arc therapy for postmastectomy treatment.

Geoffrey P Nichols, Jonas D Fontenot, John P Gibbons, Mary Ella Sanders

Abstract readEvaluation Study
In one paragraph

Article in Radiation oncology (London, England), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed.

  1. Article
  2. Article
  3. Air Quality Assessment in Pig Farming: The Italian Classyfarm.Animals : an open access journal from MDPI · 2023
    Review
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  5. Review
  6. Feasibility of 4D VMAT-CT.Biomedical physics & engineering express · 2022
    Article
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  8. Article
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  17. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Geoffrey P Nichols
Jonas D FontenotDepartment of Physics and Astronomy, Louisiana State University and Agricultural & Mechanical College, Baton Rouge, LA, USA. jfontenot@marybird.com.
John P Gibbons
Mary Ella Sanders

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo examine the feasibility of volumetric modulated arc therapy (VMAT) for post mastectomy radiotherapy (PMRT). METHODS AND MATERIALS: Fifteen PMRT patients previously treated at our clinic with helical tomotherapy (HT) were identified for the study. Planning target volumes (PTV) included the chest wall and regional lymph nodes. A systematic approach to constructing VMAT that met the clinical goals was devised. VMAT plans were then constructed for each patient and compared with HT plans with which they had been treated. The resulting plans were compared on the basis of PTV coverage; dose homogeneity index (DHI) and conformity index (CI); dose to organs at risk (OAR); tumor control probability (TCP), normal tissue complication probability (NTCP) and secondary cancer complication probability (SCCP); and treatment delivery time. Differences were tested for significance using the paired Student's t-test.

resultsBoth modalities produced clinically acceptable PMRT plans. VMAT plans showed better CI (p<0.01) and better OAR sparing at low doses than HT plans, particularly at doses less than 5 Gy. On the other hand, HT plans showed better DHI (p<0.01) and showed better OAR sparing at higher doses. Both modalities achieved nearly 100% tumor control probability and approximately 1% NTCP in the lungs and heart. VMAT showed lower SCCP than HT (p<0.01), though both plans showed higher SCCP values than conventional mixed beam (electron-photon) plans reported by our group previously. VMAT plans required 66.2% less time to deliver than HT.

conclusionsBoth VMAT and HT provide acceptable treatment plans for PMRT. Both techniques are currently utilized at our institution.

Indexed as

MastectomyRadiotherapy, Intensity-ModulatedAdultAgedAged, 80 and overBreast NeoplasmsCombined Modality TherapyFeasibility StudiesFemaleHumansMiddle AgedOrgans at RiskPostoperative PeriodRadiotherapy Planning, Computer-Assisted

Identifiers

PMID24571913
PMCPMC3984750

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.