ArticleArtificial organs2014
Temporal leukocyte numbers and granulocyte activation in pulsatile and rotary ventricular assist device patients.
Article in Artificial organs, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 30 citations in OpenAlex.
- Blood perfusion through ventricular assist devices induces erythrocytes to interact with leukocytes.Biochemistry and biophysics reports · 2025Article
- Increased phagocytosis capacity of circulating neutrophils in patients on continuous flow ventricular assist device support.Artificial organs · 2024Article
- Hemocompatibility and biophysical interface of left ventricular assist devices and total artificial hearts.Blood · 2024Review
- Influence of Hematocrit Level and Integrin αCellular and molecular bioengineering · 2024Article
- Neutrophil dysfunction due to continuous mechanical shear exposure in mechanically assisted circulation in vitro.Artificial organs · 2022Article
- The Inflammatory Response to Ventricular Assist Devices.Frontiers in immunology · 2018Review
- Visualization and analysis of biomaterial-centered thrombus formation within a defined crevice under flow.Biomaterials · 2016Article
- Real time visualization and characterization of platelet deposition under flow onto clinically relevant opaque surfaces.Journal of biomedical materials research. Part A · 2015Article
- The CentriMag centrifugal blood pump as a benchmark for in vitro testing of hemocompatibility in implantable ventricular assist devices.Artificial organs · 2015Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Individual ventricular assist device (VAD) design may affect leukocytes and impact immunity. Few studies have presented leukocyte and infection profiles in VAD patients over the course of the implant period. CD11b (MAC-1) expression on granulocytes is an indicator of activation during inflammation, mediating extravasation and the release of reactive oxygen species in tissue. No reported studies have presented MAC-1 expression on circulating granulocytes in VAD patients. Fifty-six patients implanted at a single center with a HeartMate II (HMII; n = 32), HeartWare (HW; n = 12), or Thoratec pneumatic VAD (PVAD; n = 12) between 1999 and 2011 were followed for 120 days of support. The leukocyte profiles and infectious events of all patients were evaluated; additionally, a subset had MAC-1 expression on circulating granulocytes was measured (HMII n = 9; HW n = 7; PVAD n = 4). All groups exhibited a significant peak in leukocyte numbers at postoperative day (POD) 14 while simultaneously experiencing a significant decrease in hematocrit. HMII patients exhibited a 3.2-fold increase in granulocyte MAC-1 expression at POD 14, and the temporal trend over the implant period differed from that experienced by HW patients. Further, HW patients experienced significantly fewer infection events. Alterations in leukocyte profiles and granulocyte activation experienced by VAD patients appear to be device-specific. Elevations in leukocyte activation may be related to an increased risk for infection, although the specific relationship between these phenomena in this patient group is not known.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.