ArticleNetwork (Bristol, England)
Effect of heterogeneity and noise on cross frequency phase-phase and phase-amplitude coupling.
Article in Network (Bristol, England). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Stochastic slowly adapting ionic currents may provide a decorrelation mechanism for neural oscillators by causing wander in the intrinsic period.Journal of neurophysiology · 2016Article
- Feedback control of variability in the cycle period of a central pattern generator.Journal of neurophysiology · 2015Article
- Phase-resetting as a tool of information transmission.Current opinion in neurobiology · 2015Review
- Slow noise in the period of a biological oscillator underlies gradual trends and abrupt transitions in phasic relationships in hybrid neural networks.PLoS computational biology · 2014Article
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Authors and funding
4 authors.
Funding
Abstract
Cross-frequency coupling is hypothesized to play a functional role in neural computation. We apply phase resetting theory to two types of cross-frequency coupling that can occur when a slower oscillator periodically forces one or more oscillators: phase-phase coupling, in which the two oscillations are phase-locked, and phase-amplitude coupling, in which the amplitude of the driven oscillation is modulated. Our first result is that the shape of the phase resetting curve predicts the tightness of locking to a pulsatile forcing periodic input at any ratio of forced to intrinsic period; the tightness of the locking decreases as the ratio increases. Theoretical expressions were obtained for the probability density of the phases for a population of heterogeneous oscillators or a noisy single oscillator. Results were confirmed using two types of simulated networks and experiments on hippocampal CA1 neurons. Theoretical expressions were also obtained and confirmed for the probability density of N spike times within a single cycle of low frequency forcing. The second result is a suggested mechanism for phase-amplitude coupling in which progressive desynchronization leads to decreasing amplitude during a low frequency forcing cycle. Network simulations confirmed the theoretical viability of this mechanism, and that it generalizes to more diffuse input.
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