ArticleIranian journal of basic medical sciences2013
Expression of acrA and acrB Genes in Esherichia coli Mutants with or without marR or acrR Mutations.
Article in Iranian journal of basic medical sciences, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed.
- Genomic profiling of ESBL/AmpC-producingFrontiers in microbiology · 2026Article
- Escherichia coli resistance mechanism AcrAB-TolC efflux pump interactions with commonly used antibiotics: a molecular dynamics study.Scientific reports · 2024Article
- Boosting the Antibacterial Activity of Azithromycin on Multidrug-ResistantInternational journal of molecular sciences · 2023Article
- Biofilm and Gene Expression Characteristics of the Carbapenem-Resistant Enterobacterales,International journal of environmental research and public health · 2022Article
- Hybrid Inhibitors of DNA Gyrase A and B: Design, Synthesis and Evaluation.Pharmaceutics · 2020Article
- Identification ofMicrobiology insights · 2019Article
- Local Repressor AcrR Regulates AcrAB Efflux Pump Required for Biofilm Formation and Virulence inFrontiers in cellular and infection microbiology · 2018Article
- Expression of TolC and Organic Solvent Tolerance of Escherichia Coli Ciprofloxacin Resistant Mutants.Iranian journal of pharmaceutical research : IJPR · 2017Article
- Antimicrobial susceptibility and analysis of macrolide resistance genes in Streptococcus pneumoniae isolated in Hamadan.Iranian journal of basic medical sciences · 2014Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
OBJECTIVE(S): The major antibiotic efflux pump of Esherichia coli is AcrAB-TolC. The first part of the pump, AcrAB, is encoded by acrAB operon. The expression of this operon can be kept elevated by overexpression of an activator, MarA following inactivation of MarR and AcrR repressors due to mutation in encoding genes, marR and acrR, respectively. The aims of this research were to use E. coli mutants with or without mutation in marR to search for the presence of possible mutation in acrR and to quantify the expression of acrAB. MATERIALS AND
methodsThe DNA binding region of acrR gene in these mutants were amplified by PCR and sequenced. The relative expression of acrA and acrB were determined by real time PCR.
resultsRESULTS showed that W26 and C14 had the same mutation in acrR, but none of the mutants overexpressed acrA and acrB in comparison with wild type strain.
conclusionsThe effect of marR or acrR mutation on acrAB overexpression is dependent on levels of resistance to tetracycline and ciprofloxacin.
Indexed as
Identifiers
24570831PMC3933802What OpenQuestion holds
Registered trials
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